Li Zhi-Yuan, Yang Yan-Ting, Hong Jue, Zhang Dan, Huang Xiao-Fei, Wu Li-Jie, Wu Huan-Gan, Shi Zheng, Liu Jie, Zhu Yi, Ma Xiao-Peng
Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Zhejiang Provincial Hospital of Traditional Chinese Medicine, Hangzhou, Zhejiang Province, China.
Neural Regen Res. 2017 Sep;12(9):1472-1478. doi: 10.4103/1673-5374.215259.
Herb-partitioned moxibustion can effectively mitigate visceral pain, a major symptom in inflammatory bowel disease, but the analgesic mechanism is still unclear. Moreover, extracellular signal-regulated kinase, substance P, and neurokinin-1 are involved in formation of central hyperalgesia. Thus, we postulated that the analgesic effect of herb-partitioned moxibustion may be associated with these factors. Accordingly, in this study, we established an inflammatory bowel disease visceral pain model in rat by enema with a mixed solution of 5% trinitrobenzenesulfonic acid and 50% ethanol. Bilateral (ST25) and (CV6) points were selected for herb-partitioned moxibustion. Our results showed that herb-partitioned moxibustion improved visceral pain and down-regulated extracellular signal-regulated kinase, substance P, and neurokinin-1 protein and mRNA expression in dorsal root ganglia. These results indicate that down-regulation of extracellular signal-regulated kinase, substance P, and neurokinin-1 protein and mRNA may be a central mechanism for the analgesic effect of herb-partitioned moxibustion.
隔药饼灸可有效减轻炎症性肠病的主要症状——内脏疼痛，但镇痛机制尚不清楚。此外，细胞外信号调节激酶、P物质和神经激肽-1参与中枢性痛觉过敏的形成。因此，我们推测隔药饼灸的镇痛作用可能与这些因素有关。据此，在本研究中，我们通过用5%三硝基苯磺酸和50%乙醇的混合溶液灌肠建立大鼠炎症性肠病内脏疼痛模型。选择双侧（ST25）和（CV6）穴位进行隔药饼灸。我们的结果表明，隔药饼灸改善了内脏疼痛，并下调了背根神经节中细胞外信号调节激酶、P物质和神经激肽-1蛋白及mRNA的表达。这些结果表明，细胞外信号调节激酶、P物质和神经激肽-1蛋白及mRNA的下调可能是隔药饼灸镇痛作用的中枢机制。
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