Saeed Abkhiz, Amin Valizade Hasanloei Mohammad, Alireza Mahoori, Hadi Hooshiar, Rahimeh Alizadeh Osalou
Internist, Nephrologist, Assistant Professor of Urmia University of Medical Sciences.
Anesthesiologist, fellowship of intensive care medicine, Associate Professor of Urmia University of Medical Sciences.
Maedica (Bucur). 2017 Jun;12(2):95-100.
Acute kidney injury is the sudden and almost complete loss of renal function with reduced glomerular filtration rate, and it occurs whenever the kidneys are unable to excrete metabolic waste products.
This randomized double-blinded clinical trial was performed in an intensive care unit (ICU) of a university educational hospital. After randomization with a random assigning table of numbers, patients were divided into two groups: an intervention group and a control group. The patients' daily blood urea nitrogen and creatinine levels were measured and changes were recorded. The statin group received a tablet of atorvastatin 40 mg daily (Abidi Pharmacy Production). Moreover, patients' baseline vital signs and changes in serum blood urea nitrogen, creatinine, mechanical ventilation requirement, need for dialysis, ICU stays, and mortality were recorded in both groups. SPSS version 20 software was used for data analysis. P value <0.05 was considered significant.
The mean intubation time for the intervention and control groups was 4.44±1.8 and 3.46±2.02, respectively, and the mean mechanical ventilation time was 2.14±2.15 and 2.34±2.07 days, respectively. The mean ICU stay was 4.91±3.3 days for the intervention group and 4.67±2.67 days for the control group. Throughout the study duration, the mean dialysis requirement frequency was 4.66±1.2 times in the intervention group and 5.54 ±1.75 times in the control group. Two patients in the intervention group and three patients in the control group died. There was no statistically significant difference in mortality between the two groups (P >0.05).
The effects of statins on the different stages of acute kidney injury and its outcomes are yet challengeable, so we recommend conducting further studies with larger sample sizes.
急性肾损伤是肾小球滤过率降低导致的肾功能突然且几乎完全丧失，只要肾脏无法排出代谢废物就会发生。
本随机双盲临床试验在一所大学教学医院的重症监护病房（ICU）进行。使用随机数字分配表进行随机分组后，患者被分为两组：干预组和对照组。测量患者每日的血尿素氮和肌酐水平并记录变化。他汀类药物组每天服用一片40毫克阿托伐他汀（阿比迪制药生产）。此外，记录两组患者的基线生命体征以及血清血尿素氮、肌酐、机械通气需求、透析需求、ICU住院时间和死亡率的变化。使用SPSS 20版软件进行数据分析。P值<0.05被认为具有统计学意义。
干预组和对照组的平均插管时间分别为4.44±1.8天和3.46±2.02天，平均机械通气时间分别为2.14±2.15天和2.34±2.07天。干预组的平均ICU住院时间为4.91±3.3天，对照组为4.67±2.67天。在整个研究期间，干预组的平均透析需求频率为4.66±1.2次，对照组为5.54±1.75次。干预组有2例患者死亡，对照组有3例患者死亡。两组之间的死亡率无统计学显著差异（P>0.05）。
他汀类药物对急性肾损伤不同阶段及其结果的影响仍存在争议，因此我们建议进行更大样本量的进一步研究。
