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本文引用的文献

1
p38 MAPK Inhibition Improves Heart Function in Pressure-Loaded Right Ventricular Hypertrophy.p38丝裂原活化蛋白激酶抑制改善压力负荷性右心室肥厚的心脏功能
Am J Respir Cell Mol Biol. 2017 Nov;57(5):603-614. doi: 10.1165/rcmb.2016-0374OC.
2
The reversal of pulmonary vascular remodeling through inhibition of p38 MAPK-alpha: a potential novel anti-inflammatory strategy in pulmonary hypertension.通过抑制p38丝裂原活化蛋白激酶α逆转肺血管重塑：肺动脉高压中一种潜在的新型抗炎策略。
Am J Physiol Lung Cell Mol Physiol. 2015 Aug 15;309(4):L333-47. doi: 10.1152/ajplung.00038.2015. Epub 2015 May 29.
3
Upregulated expression of STIM2, TRPC6, and Orai2 contributes to the transition of pulmonary arterial smooth muscle cells from a contractile to proliferative phenotype.STIM2、TRPC6和Orai2表达上调促进肺动脉平滑肌细胞从收缩表型向增殖表型转变。
Am J Physiol Cell Physiol. 2015 Apr 15;308(8):C581-93. doi: 10.1152/ajpcell.00202.2014. Epub 2015 Feb 11.
4
Novel mechanisms of sildenafil in pulmonary hypertension involving cytokines/chemokines, MAP kinases and Akt.西地那非治疗肺动脉高压的新机制：涉及细胞因子/趋化因子、丝裂原活化蛋白激酶和蛋白激酶B
PLoS One. 2014 Aug 18;9(8):e104890. doi: 10.1371/journal.pone.0104890. eCollection 2014.
5
Losmapimod, a novel p38 mitogen-activated protein kinase inhibitor, in non-ST-segment elevation myocardial infarction: a randomised phase 2 trial.洛司帕米莫，一种新型的 p38 丝裂原活化蛋白激酶抑制剂，在非 ST 段抬高型心肌梗死中的应用：一项随机 2 期试验。
Lancet. 2014 Sep 27;384(9949):1187-95. doi: 10.1016/S0140-6736(14)60417-7. Epub 2014 Jun 12.
6
Sildenafil treatment in established right ventricular dysfunction improves diastolic function and attenuates interstitial fibrosis independent from afterload.对已发生的右心室功能障碍进行西地那非治疗可改善舒张功能，并减轻间质纤维化，且独立于后负荷。
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7
Right heart adaptation to pulmonary arterial hypertension: physiology and pathobiology.右心对肺动脉高压的适应：生理学和病理生物学。
J Am Coll Cardiol. 2013 Dec 24;62(25 Suppl):D22-33. doi: 10.1016/j.jacc.2013.10.027.
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Dev Cell. 2012 Oct 16;23(4):705-15. doi: 10.1016/j.devcel.2012.08.017. Epub 2012 Sep 27.
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NADPH oxidase-dependent redox signaling in human heart failure: relationship between the left and right ventricle.人类心力衰竭中烟酰胺腺嘌呤二核苷酸磷酸氧化酶依赖性氧化还原信号传导：左右心室之间的关系
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Is p38 MAPK a Dark Force in Right Ventricular Hypertrophy and Failure in Pulmonary Arterial Hypertension?

作者信息

Vanderpool Rebecca R, Tang Haiyang, Rischard Franz, Yuan Jason X-J

机构信息

1 Division of Translational and Regenerative Medicine University of Arizona College of Medicine Tucson, Arizona.

2 Division of Pulmonary, Allergy, Critical Care and Sleep Medicine University of Arizona College of Medicine Tucson, Arizona.

出版信息

Am J Respir Cell Mol Biol. 2017 Nov;57(5):506-508. doi: 10.1165/rcmb.2017-0197ED.

DOI:10.1165/rcmb.2017-0197ED
PMID:29090954
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5705908/
Abstract
摘要