Yam Xue Yan, Preiser Peter R
School of Biological Sciences, Nanyang Technological University, 637551, Singapore.
Mol Biosyst. 2017 Nov 21;13(12):2498-2508. doi: 10.1039/c7mb00502d.
Host immune evasion is a key strategy for the continual survival of many microbial pathogens including Apicomplexan protozoan: Plasmodium spp., the causative agent of Malaria. The malaria parasite has evolved a variety of mechanisms to evade the host immune responses within its two hosts: the female Anopheles mosquito vector and vertebrate host. In this review, we will focus on the molecular mechanisms of the immune evasion strategies used by the Plasmodium parasite at the blood stage which is responsible for the clinical manifestations of human malaria. We also aim to provide some insights on the potential targets for malaria interventions through the recent advancement in understanding the molecular biology of the parasite.
宿主免疫逃避是包括顶复门原生动物疟原虫属（引起疟疾的病原体）在内的许多微生物病原体持续生存的关键策略。疟原虫已经进化出多种机制，以在其两个宿主（雌性按蚊媒介和脊椎动物宿主）内逃避宿主免疫反应。在这篇综述中，我们将重点关注疟原虫在血液阶段用于免疫逃避策略的分子机制，该阶段是人类疟疾临床表现的原因。我们还旨在通过最近在了解该寄生虫分子生物学方面的进展，为疟疾干预的潜在靶点提供一些见解。
