Department of Basic Medical College, Jining Medical University, Jining, Shandong, China.
College of Science, Qufu Normal University, Qufu, Shandong, China.
J Cell Biochem. 2018 Apr;119(4):2999-3006. doi: 10.1002/jcb.26476. Epub 2017 Dec 26.
Angiogenesis refers to the new blood vessels deriving from the existing blood vessels, and it is a complex regulatory process. Angiogenesis is associated with the normal development of the body and tumor growth and migration. The imbalance of histone deacetylase, as an epigenetic modification, could induce the production of diseases, such as cancer, metabolic diseases, etc., and it also plays an important role in angiogenesis. Many researches indicate that class II HDACs nuclear shuttle and its phosphorylation are necessary for the diseases and the protection of the collective itself. This paper will make a review for the relationship between II HDACs and angiogenesis under physiological and pathologic categories, looking forward to the disease treatment in the future.
血管生成是指新的血管从现有的血管中衍生出来，它是一个复杂的调节过程。血管生成与身体的正常发育以及肿瘤的生长和迁移有关。组蛋白去乙酰化酶的失衡作为一种表观遗传修饰，可以诱导癌症、代谢疾病等疾病的产生，它在血管生成中也起着重要作用。许多研究表明，II 类 HDACs 的核穿梭及其磷酸化对于疾病和集体自身的保护是必要的。本文将综述 II 类 HDACs 在生理和病理条件下与血管生成的关系，以期为未来的疾病治疗提供思路。
