Yoshizaki Kaichi, Koike Kohei, Kimura Ryuichi, Osumi Noriko
Department of Developmental Neuroscience, United Centers for Advanced Research and Translational Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan.
Department of Pathology, Institute for Developmental Research, Aichi Human Service Center, Aichi, Japan.
PLoS One. 2017 Nov 1;12(11):e0186798. doi: 10.1371/journal.pone.0186798. eCollection 2017.
The understanding of individual diversity and its link to brain functions is a fundamental issue in neurobiology. Studies in mice have mainly focused on the investigation of behavior traits in adulthood, whereas longitudinal analyses are largely uninvestigated. Here we have conducted systematic behavior tests in individual mice (C57BL6/J, male), comparing phenotypes at early postnatal stages and in adulthood. Each animal showed different scores in individual behavior tests. However, we observed an inverse correlation between repetitive behavior in the Morris water maze test and sociability in the 3-chamber social interaction test; an increase in repetitive behaviors was associated with poor sociability. In longitudinal analyses, the emission of ultrasonic vocalization during maternal separation at postnatal day 6 in pups was correlated positively with sociability and negatively with spatial memory. Our results show a possibility that individual differences in communication between pups and their mother in infancy is a predictive indicator for sociability and cognitive performance as an adult.
对个体差异及其与脑功能的联系的理解是神经生物学中的一个基本问题。对小鼠的研究主要集中在成年期行为特征的调查上，而纵向分析在很大程度上未被研究。在这里，我们对个体小鼠（C57BL6/J，雄性）进行了系统的行为测试，比较了出生后早期阶段和成年期的表型。每只动物在个体行为测试中表现出不同的分数。然而，我们观察到在莫里斯水迷宫测试中的重复行为与三室社交互动测试中的社交能力之间存在负相关；重复行为的增加与社交能力差有关。在纵向分析中，幼崽出生后第6天母体分离期间发出的超声波鸣叫与社交能力呈正相关，与空间记忆呈负相关。我们的结果表明，幼崽与其母亲在婴儿期沟通中的个体差异有可能作为成年后社交能力和认知表现的预测指标。
