Heerkens Hanne D, van Berkel Lisanne, Tseng Dorine S J, Monninkhof Evelyn M, van Santvoort Hjalmar C, Hagendoorn Jeroen, Borel Rinkes Inne H M, Lips Irene M, Intven Martijn, Molenaar I Quintus
Department of Radiation Oncology, University Medical Center Utrecht, Utrecht, The Netherlands.
Department of Radiation Oncology, University Medical Center Utrecht, Utrecht, The Netherlands; Department of Surgery, University Medical Center Utrecht, Utrecht, The Netherlands.
HPB (Oxford). 2018 Feb;20(2):188-195. doi: 10.1016/j.hpb.2017.09.003. Epub 2017 Oct 29.
Surgery for pancreatic cancer yields significant morbidity and mortality risks and survival is limited. Therefore, the influence of complications on quality of life (QoL) after pancreatic surgery is important. This study compares QoL in patients with and without severe complications after surgery for pancreatic (pre-)malignancy.
This prospective cohort study scored complications after pancreatic surgery according to the Clavien-Dindo system and the definitions of the International Study Group of Pancreatic Surgery. QoL was measured by the RAND36 questionnaire, the European Organization for Research and Treatment of Cancer core questionnaire (QLQ-C30) and the pancreas specific QLQ-PAN26. QoL in patients with severe complications was compared with QoL in patients with no or mild complications over a period of 12 months. Analysis was performed with linear mixed models for repeated measurements.
Between March 2012 and July 2016, 137 patients were included. Sixty-eight patients (50%) had at least 1 severe complication. There were no statistically significant and clinically relevant differences between both groups in QoL up to 12 months after surgery.
In this study, no differences in QoL between patients with and without severe postoperative complications were encountered during the first 12 months after surgery for pancreatic (pre-)malignancy.
http://www.clinicaltrials.gov Identifier: NCT02175992.
胰腺癌手术具有较高的发病和死亡风险，且生存率有限。因此，并发症对胰腺手术后生活质量（QoL）的影响至关重要。本研究比较了胰腺（癌前）病变手术后有严重并发症和无严重并发症患者的生活质量。
这项前瞻性队列研究根据Clavien-Dindo系统和国际胰腺手术研究组的定义对胰腺手术后的并发症进行评分。生活质量通过兰德36项问卷、欧洲癌症研究与治疗组织核心问卷（QLQ-C30）和胰腺特异性问卷QLQ-PAN26进行测量。在12个月的时间里，将有严重并发症患者的生活质量与无并发症或轻度并发症患者的生活质量进行比较。采用线性混合模型进行重复测量分析。
2012年3月至2016年7月期间，共纳入137例患者。68例患者（50%）至少有1种严重并发症。两组患者术后12个月内的生活质量在统计学上无显著差异，且无临床相关性差异。
在本研究中，胰腺（癌前）病变手术后的前12个月内，有严重术后并发症和无严重术后并发症的患者在生活质量方面没有差异。
http://www.clinicaltrials.gov 标识符：NCT02175992。
