Phase II trial of continuous-infusion iproplatin (CHIP) and 5-fluorouracil (5-FU) in advanced colorectal carcinoma.
作者信息
Petrelli N J, Creaven P J, Herrera L, Mittelman A
机构信息
Roswell Park Memorial Institute, Department of Surgical Oncology, Buffalo, NY 14263.
出版信息
Cancer Chemother Pharmacol. 1989;23(1):61-2. doi: 10.1007/BF00258461.
PMID:2909291
Abstract
Following the observation of antitumor activity for the combination of 5-fluorouracil (5-FU) and cisplatin in metastatic colorectal carcinoma, the combination of 5-FU and iproplatin was tested, also in colorectal carcinoma, in the hope of attaining equivalent activity without the nephrotoxicity observed with 5-FU/cisplatin. However, no responses were achieved with 5-FU/iproplatin.
摘要
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