The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.
St. Jude Children's Research Hospital, Memphis, Tennessee.
Clin Cancer Res. 2017 Nov 1;23(21):e133-e137. doi: 10.1158/1078-0432.CCR-17-2026.
At least 10% of children with cancer harbor a disease-associated pathogenic variant in a known cancer predisposition gene. It is widely accepted that pathogenic variants affecting other genes, epigenetic factors, or abnormalities in additional gene products may contribute to the etiology of many more childhood cancers. Effective preventive measures exist for only a few cancer types associated with predisposing conditions, but the development and implementation of surveillance protocols aimed at reducing morbidity and mortality in at-risk children through the early detection of cancer has emerged as an important clinical tool. The articles in this series present international consensus generated recommendations for surveillance for a wide spectrum of cancer predisposition syndromes affecting children. In this article, we explore the challenges and opportunities for researchers and practitioners in the many fields affiliated with pediatric cancer, and we offer insights into what the future might hold as we continue our efforts to mitigate the impact of cancer susceptibility on children, their families and society.
至少有 10%的癌症患儿携带有已知的癌症易感基因的致病性变异。人们普遍认为，影响其他基因、表观遗传因素或其他基因产物异常的致病性变异可能导致更多儿童癌症的发生。虽然只有少数几种与易患疾病相关的癌症类型存在有效的预防措施，但通过早期发现癌症来减少高危儿童发病率和死亡率的监测方案的制定和实施已成为一种重要的临床工具。本系列中的文章提出了国际共识，为广泛影响儿童的各种癌症易感综合征的监测制定了建议。在本文中，我们探讨了与儿科癌症相关的多个领域的研究人员和从业者所面临的挑战和机遇，并深入探讨了随着我们继续努力减轻癌症易感性对儿童、其家庭和社会的影响，未来可能会出现哪些情况。
