Nonaka Saori, Shiratsuchi Akiko, Nagaosa Kaz, Nakanishi Yoshinobu
Graduate School of Medical Sciences, Kanazawa University.
Biol Pharm Bull. 2017;40(11):1819-1827. doi: 10.1248/bpb.b17-00478.
Cells that have become unwanted by the body need to be selectively, rapidly, and safely removed. The removal of these cells is achieved by apoptosis-dependent phagocytosis: unwanted cells are induced to undergo apoptosis and given susceptibility to phagocytosis. Phagocytes recognize these cells using engulfment receptors that bind substances expressed on the surface of target cells during the apoptotic process. The phagocytic elimination of cells undergoing apoptosis is a mechanism that is conserved among multicellular organisms. Malfunctions in this process may lead to structural and functional defects in morphogenesis and tissue homeostasis. Therefore, molecules involved in this phenomenon may be targeted in medical treatments. The mechanisms responsible for the apoptosis-dependent phagocytosis of unwanted cells as well as its physiological and pathological consequences are described herein.
身体中不需要的细胞需要被选择性、快速且安全地清除。这些细胞的清除是通过凋亡依赖性吞噬作用实现的：不需要的细胞被诱导发生凋亡，并变得易于被吞噬。吞噬细胞利用吞噬受体识别这些细胞，这些受体在凋亡过程中结合靶细胞表面表达的物质。对正在经历凋亡的细胞进行吞噬清除是多细胞生物中保守的一种机制。这一过程中的功能障碍可能导致形态发生和组织稳态方面的结构和功能缺陷。因此，参与这一现象的分子可能成为医学治疗的靶点。本文描述了负责对不需要的细胞进行凋亡依赖性吞噬作用的机制及其生理和病理后果。
