3-取代氧化吲哚与外消旋仲烷基卤化物的非对映和对映选择性相转移烷基化反应。
Diastereo- and enantioselective phase-transfer alkylation of 3-substituted oxindoles with racemic secondary alkyl halides.
作者信息
Ohmatsu Kohsuke, Furukawa Yukino, Kiyokawa Mari, Ooi Takashi
机构信息
Institute of Transformative Bio-Molecules (WPI-ITbM), and Department of Molecular and Macromolecular Chemistry, Graduate School of Engineering, Nagoya University, Chikusa, Nagoya 464-8601, Japan.
出版信息
Chem Commun (Camb). 2017 Dec 7;53(98):13113-13116. doi: 10.1039/c7cc07122a.
PMID:29094112
Abstract
A catalytic asymmetric alkylation of fully substituted enolates with racemic, non-activated secondary alkyl halides is described. The chiral 1,2,3-triazolium ion enables excellent diastereo- and enantiocontrol via enantiofacial discrimination of prochiral enolates and kinetic resolution of secondary halides.
摘要
本文描述了一种用外消旋、未活化仲卤代烃对全取代烯醇盐进行催化不对称烷基化反应。手性1,2,3 - 三唑鎓离子通过前手性烯醇盐的对映面识别和仲卤代烃的动力学拆分实现了出色的非对映和对映选择性控制。
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