Brooks D P, Nutting D F, Crofton J T, Share L
Department of Physiology and Biophysics, University of Tennessee, Memphis.
Diabetes. 1989 Jan;38(1):54-7. doi: 10.2337/diab.38.1.54.
Rats were administered streptozocin (STZ; 50 or 75 mg/kg i.v., tail vein) or vehicle. Approximately 2 wk later, venous and arterial catheters was implanted for subsequent (24 h later) vasopressin, electrolyte, and hemodynamic measurements. STZ-induced diabetic (STZ-D) rats demonstrated a dose-dependent increase in the plasma glucose concentration, plasma osmolality, and plasma vasopressin concentration. Mean arterial blood pressure (MABP) was unchanged, but heart rate was reduced. Diabetes-prone BB rats, maintained on or withdrawn from insulin treatment for 24-48 h, and diabetes-resistant rats were instrumented and studied as above. Spontaneous-diabetes-prone rats demonstrated increase in plasma glucose concentration and plasma osmolality similar to STZ-D rats but had significantly greater plasma vasopressin concentrations. The significant decrease in MABP observed in these animals probably contributed to the enhanced vasopressin response. We conclude that both osmotic and cardiovascular parameters play important roles in vasopressin secretion in diabetic rats.
给大鼠静脉注射链脲佐菌素（STZ；50或75毫克/千克，经尾静脉）或赋形剂。大约2周后，植入静脉和动脉导管以便随后（24小时后）进行血管加压素、电解质和血流动力学测量。链脲佐菌素诱导的糖尿病（STZ-D）大鼠的血糖浓度、血浆渗透压和血浆血管加压素浓度呈剂量依赖性增加。平均动脉血压（MABP）未改变，但心率降低。对糖尿病倾向的BB大鼠进行胰岛素治疗24 - 48小时或停止治疗后，以及对糖尿病抵抗大鼠，按上述方法进行插管和研究。自发糖尿病倾向大鼠的血糖浓度和血浆渗透压升高，与STZ-D大鼠相似，但血浆血管加压素浓度显著更高。在这些动物中观察到的MABP显著降低可能导致了血管加压素反应增强。我们得出结论，渗透压和心血管参数在糖尿病大鼠的血管加压素分泌中都起重要作用。
