4-氨基羰基取代的1,8-萘二甲酰亚胺的模块化合成及其在单分子荧光检测中的应用
Modular synthesis of 4-aminocarbonyl substituted 1,8-naphthalimides and application in single molecule fluorescence detection.
作者信息
Hearn K N, Nalder T D, Cox R P, Maynard H D, Bell T D M, Pfeffer F M, Ashton T D
机构信息
Centre for Chemistry and Biotechnology, School of Life and Environmental Sciences, Deakin University, Waurn Ponds, 3216, Australia.
出版信息
Chem Commun (Camb). 2017 Nov 14;53(91):12298-12301. doi: 10.1039/c7cc07922b.
Robust methodology to install amide, carbamate, urea and sulfonamide functionality to the 1,8-naphthalimide scaffold has been developed and exemplified. New benzamidonaphthalimide 6, synthesised using this approach, was found to be sensitive to base whereupon fluorescence emission strongly increases (>10-fold) and red-shifts (>4000 cm). The optical properties of deprotonated 6 allow for single molecule fluorescence detection, the first example of such behaviour from this class of fluorophore.
已开发并举例说明了将酰胺、氨基甲酸酯、脲和磺酰胺官能团安装到1,8-萘二甲酰亚胺支架上的稳健方法。使用这种方法合成的新型苯甲酰胺萘二甲酰亚胺6被发现对碱敏感，在此情况下荧光发射强烈增加（>10倍）并发生红移（>4000 cm）。去质子化的6的光学性质允许进行单分子荧光检测，这是这类荧光团中此类行为的首个例子。
Zotero 插件