一种由卷曲DNA引起的新型银纳米簇荧光调控机制及其在构建低背景和大信号增强分子信标中的应用。
A new AgNC fluorescence regulation mechanism caused by coiled DNA and its applications in constructing molecular beacons with low background and large signal enhancement.
作者信息
Zhou Weijun, Dong Shaojun
机构信息
State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, P. R. China.
出版信息
Chem Commun (Camb). 2017 Nov 14;53(91):12290-12293. doi: 10.1039/c7cc06872g.
PMID:29094134
Abstract
Herein, we report a new fluorescence regulation mechanism of DNA-templated AgNCs caused by coiled DNA. Based on these phenomena, a novel dual fluorescent AgNC-MB with exponential signal enhancement and remarkably low background was developed. The AgNC-MB could effectively facilitate template design and avoid the disturbance caused by undesirable hybridization.
摘要
在此，我们报道了由卷曲DNA引起的DNA模板化银纳米簇的一种新的荧光调控机制。基于这些现象，开发了一种具有指数信号增强和极低背景的新型双荧光银纳米簇-分子信标。银纳米簇-分子信标能够有效地促进模板设计，并避免由不良杂交引起的干扰。
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