IBMM (UMR5247), Univ Montpellier, CNRS, ENSCM, Montpellier, France.
Laboratory of applied Chemistry, Faculty of Science III, Lebanese University, P.O. Box 826, Tripoli, Lebanon.
Macromol Rapid Commun. 2018 Feb;39(3). doi: 10.1002/marc.201700502. Epub 2017 Nov 2.
Advanced drug delivery systems (DDS) are easily designed following a photoiterative strategy. Multifunctional polymers are obtained by coupling building blocks of interest to an alkynated poly(ε-caprolactone) (PCL) platform via an efficient thiol-yne photoaddition. Fine-tuning over the design is achieved, as illustrated with targeting and enzyme-responsive DDS.
先进的药物传递系统（DDS）可以通过光迭代策略轻松设计。通过高效的硫醇-炔点击加成反应，将感兴趣的构建块偶联到炔丙基化的聚（ε-己内酯）（PCL）平台上，得到多功能聚合物。通过靶向和酶响应的 DDS 进行设计的微调，如图所示。
