DNA倍体、分级及分期在子宫颈癌预后中的作用
DNA ploidy, grade, and stage in prognosis of uterine cervical cancer.
作者信息
Davis J R, Aristizabal S, Way D L, Weiner S A, Hicks M J, Hagaman R M
机构信息
Department of Pathology, University of Arizona Health Sciences Center, Tucson 85724.
出版信息
Gynecol Oncol. 1989 Jan;32(1):4-7. doi: 10.1016/0090-8258(89)90840-8.
A retrospective study of 56 cases of uterine cervical squamous carcinoma evaluated DNA content, histological grade, and clinical stage as indicators of prognosis. Minimum survivor follow-up was 24 months. Following standard radiation therapy, there were 40 cures and 16 treatment failures. DNA content was measured by flow cytometry of pretreatment biopsies removed from paraffin. There were 18 diploid cases and 38 aneuploid (67.9%). Aneuploid cases included 6 with very high G2-M peaks (greater than or equal to 15% of the cell sample). DNA ploidy correlation with prognosis was not statistically significant. However, both grading by a multiple parameter method (P less than 0.0133) and staging (P less than 0.0064) were significant prognostic factors. Higher grade and stage correlated with treatment failure.
一项对56例子宫颈鳞状癌的回顾性研究将DNA含量、组织学分级和临床分期作为预后指标进行评估。最小存活者随访时间为24个月。采用标准放射治疗后，有40例治愈，16例治疗失败。通过对石蜡包埋的治疗前活检组织进行流式细胞术测量DNA含量。有18例二倍体病例和38例非整倍体病例（67.9%）。非整倍体病例包括6例G2-M峰非常高（大于或等于细胞样本的15%）的病例。DNA倍性与预后的相关性无统计学意义。然而，采用多参数方法分级（P<0.0133）和分期（P<0.0064）均为显著的预后因素。更高的分级和分期与治疗失败相关。
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