Chill Henry H, Malyanker Nirit, Karavani Gilad, Haj-Yahya Rani, Herzberg Shmuel, Bahar Raz, Shveiky David, Dior Uri P
Department of Obstetrics and Gynecology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
J Obstet Gynaecol Res. 2018 Feb;44(2):248-252. doi: 10.1111/jog.13512. Epub 2017 Nov 2.
We aimed to determine the importance of uterine position as a predicting factor of success rate in medically treated early pregnancy failure (EPF).
We carried out a retrospective cohort study at the Obstetrics and Gynecology Department of a tertiary medical center between January 2011 and June 2012. We included women diagnosed with EPF, which we defined as women diagnosed with missed abortion up to 13 gestational weeks. Patients were treated with one or two doses of 800 μg of misoprostol vaginally in accordance with the department's protocol. Demographic, clinical, and treatment success data were collected from patient electronic records.
A total of 255 women were included in our study. The success rate after treatment with misoprostol for the anterior uterine group was 78.7% as compared to the non-anterior uterine group, which achieved a success rate of 88.1%. This difference was not statistically significant (P = 0.180). In a multivariate analysis comparing patients for whom treatment with misoprostol was successful as opposed to patients for whom treatment failed, only embryonic sac size showed a statistically significant difference, measuring shorter in the success group.
Uterine position has no effect on success rate of misoprostol treatment for EPF.
我们旨在确定子宫位置作为药物治疗早期妊娠失败（EPF）成功率预测因素的重要性。
2011年1月至2012年6月期间，我们在一家三级医疗中心的妇产科开展了一项回顾性队列研究。我们纳入了被诊断为EPF的女性，我们将其定义为被诊断为妊娠13周以内稽留流产的女性。患者按照科室方案经阴道给予一剂或两剂800μg米索前列醇进行治疗。从患者电子记录中收集人口统计学、临床和治疗成功数据。
我们的研究共纳入255名女性。米索前列醇治疗后，子宫前位组的成功率为78.7%，而非子宫前位组的成功率为88.1%。这种差异无统计学意义（P = 0.180）。在一项多变量分析中，比较米索前列醇治疗成功的患者与治疗失败的患者，只有孕囊大小显示出统计学上的显著差异，成功组的孕囊较小。
子宫位置对米索前列醇治疗EPF的成功率没有影响。
