Silva Eder L, Almeida-Lafetá Rita C, Borges Ricardo M, Staerk Dan
Instituto de Pesquisas de Produtos Naturais Walter Mors, Centro de Ciências da Saúde, Universidade Federal do Rio de Janeiro, Rio de Janeiro, 21941-902, Brazil.
Department of Drug Design and Pharmacology, Faculty of Healthy and Medicinal Sciences, University of Copenhagen, Universitetsparken 2, Copenhagen, DK-2100, Denmark.
Chem Biodivers. 2018 Jan;15(1). doi: 10.1002/cbdv.201700455. Epub 2017 Dec 25.
Athenaea (Solanaceae) is an endemic genus belonging to the Brazilian Atlantic Rainforest. Recently, botanical investigations suggested the re-evaluation of the generic status of the genus Athenaea as a synonym of Aureliana. In this study, the first investigation of the Athenaea genus performed on Athenaea martiana by means of HPLC-HR-MS-SPE-NMR combined with high-resolution radical scavenging profile led to identification of several phenolic acids as radical scavengers: protocatechuic acid (1), 4-hydroxybenzoic acid (2), caffeic acid (3), vanillic acid (4), and ferulic acid (6). Additional analysis revealed a new steroidal lactone, named athenolide A (9). Their structures were elucidated by extensive use of NMR spectroscopy as well as HR-MS. Chemotaxonomic considerations based on these results supported the chemical relationships between the Athenaea and Aureliana genera, in agreement with the recent botanical findings.
阿泰纳亚属（茄科）是一个隶属于巴西大西洋雨林的特有属。最近，植物学研究表明，应重新评估阿泰纳亚属作为奥雷利亚纳属同义词的分类地位。在本研究中，首次通过HPLC-HR-MS-SPE-NMR结合高分辨率自由基清除谱对马氏阿泰纳亚进行了研究，从而鉴定出几种作为自由基清除剂的酚酸：原儿茶酸（1）、4-羟基苯甲酸（2）、咖啡酸（3）、香草酸（4）和阿魏酸（6）。进一步分析发现了一种新的甾体内酯，命名为阿泰诺内酯A（9）。通过广泛使用核磁共振光谱以及高分辨率质谱对其结构进行了阐明。基于这些结果的化学分类学考量支持了阿泰纳亚属与奥雷利亚纳属之间的化学关系，这与最近的植物学研究结果一致。
