轻度创伤性脑损伤后有广泛和轻微脑震荡后症状的患者以及健康对照者的扩散磁共振成像结果：一项横断面研究
Diffusion MRI findings in patients with extensive and minimal post-concussion symptoms after mTBI and healthy controls: a cross sectional study.
作者信息
Næss-Schmidt Erhard Trillingsgaard, Blicher Jakob Udby, Tietze Anna, Rask Charlotte Ulrikka, Svendsen Susanne Wulff, Schröder Andreas, Thastum Mille Møller, Tuborgh Astrid Høeg, Frederiksen Oana-Veronica, Østergaard Leif, Eskildsen Simon Fristed, Hansen Brian, Jespersen Sune, Nielsen Jørgen Feldbæk
机构信息
a Dept of Clinical Medicine , Hammel Neurorehabilitation Centre and University Research Clinic, Aarhus University , Hammel , Denmark.
b Center of Functionally Integrative Neuroscience, Institute of Clinical Medicine , Aarhus University , Aarhus , Denmark.
出版信息
Brain Inj. 2018;32(1):91-98. doi: 10.1080/02699052.2017.1377352. Epub 2017 Nov 2.
PRIMARY OBJECTIVES
We hypothesized that the microstructure of the corpus callosum, thalamus and hippocampus, as measured with diffusion and Mean of the Kurtosis Tensor (MKT) MRI, differs between healthy subjects and patients with extensive and minimal post-concussion symptoms (PCS) and that MKT measures correlate with PCS severity and self-reported cognitive symptoms.
RESEARCH DESIGN
A cross-sectional study comparing patients with extensive PCS and patients with minimal PCS 2-5 months after mild traumatic brain injury (mTBI) with each other and with an external healthy control group.
METHODS AND PROCEDURES
Diffusion MRI was obtained in 25 patients with extensive PCS and in 25 patients with minimal PCS as measured by the Rivermead Post-concussion Symptoms Questionnaire. The patients were matched on age, sex and time since accident. Data from an external healthy control group (n = 27) was included.
MAIN OUTCOME AND RESULTS
There was no difference in MKT between the two groups with mTBI and no correlation between MKT and PCS. There was no difference between the three groups in other diffusion measures.
CONCLUSIONS
Our results did not point to microstructural changes in the corpus callosum, thalamus and hippocampus in relation to PCS after mTBI.
主要目标
我们假设，通过扩散张量成像和峰度张量均值（MKT）MRI测量的胼胝体、丘脑和海马体的微观结构，在健康受试者与有广泛和轻微脑震荡后症状（PCS）的患者之间存在差异，并且MKT测量值与PCS严重程度和自我报告的认知症状相关。
研究设计
一项横断面研究，比较轻度创伤性脑损伤（mTBI）后2 - 5个月有广泛PCS的患者、有轻微PCS的患者以及外部健康对照组。
方法与步骤
通过Rivermead脑震荡后症状问卷测量，对25例有广泛PCS的患者和25例有轻微PCS的患者进行了扩散张量成像。患者在年龄、性别和事故发生后的时间方面进行了匹配。纳入了来自外部健康对照组（n = 27）的数据。
主要结果
两组mTBI患者的MKT无差异，MKT与PCS之间无相关性。三组在其他扩散测量方面无差异。
结论
我们的结果并未表明mTBI后胼胝体、丘脑和海马体的微观结构与PCS有关。
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