Protein Structure and Biology: Poster Abstracts.
出版信息
Prion. 2013 Apr/May;7(sup1):81-104. doi: 10.4161/pri.24866.
Abstract
摘要
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Protein Structure and Biology: Poster Abstracts.蛋白质结构与生物学：海报摘要
Prion. 2013 Apr/May;7(sup1):81-104. doi: 10.4161/pri.24866.
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Molecular mechanisms of prion pathogenesis.朊病毒致病的分子机制。
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Destabilizing polymorphism in cervid prion protein hydrophobic core determines prion conformation and conversion efficiency.鹿科动物朊病毒蛋白疏水核心的不稳定多态性决定了朊病毒的构象和转化效率。
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[Prion biology: update].[朊病毒生物学：最新进展]
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An antipsychotic drug exerts anti-prion effects by altering the localization of the cellular prion protein.一种抗精神病药物通过改变细胞朊蛋白的定位发挥抗朊病毒作用。
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本文引用的文献
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3D-RISM-Dock: A New Fragment-Based Drug Design Protocol.3D-RISM对接：一种基于片段的新药物设计方案。
J Chem Theory Comput. 2012 Sep 11;8(9):3356-72. doi: 10.1021/ct300257v. Epub 2012 Aug 21.
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Post-translational changes to PrP alter transmissible spongiform encephalopathy strain properties.朊病毒蛋白的翻译后修饰改变了传染性海绵状脑病株的特性。
EMBO J. 2013 Mar 6;32(5):756-69. doi: 10.1038/emboj.2013.6. Epub 2013 Feb 8.
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A systematic mammalian genetic interaction map reveals pathways underlying ricin susceptibility.系统性哺乳动物遗传互作图谱揭示蓖麻毒素易感性的相关途径。
Cell. 2013 Feb 14;152(4):909-22. doi: 10.1016/j.cell.2013.01.030. Epub 2013 Feb 8.
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Characterization of peptides obtained from digests of bovine brain which accelerate structural conversions of the recombinant bovine prion protein.从牛脑消化物中获得的肽的特性，这些肽可加速重组牛朊病毒蛋白的结构转化。
FEBS Lett. 2013 Mar 18;587(6):673-6. doi: 10.1016/j.febslet.2013.01.033. Epub 2013 Feb 1.
5
The highly conserved, N-terminal (RXXX)8 motif of mouse Shadoo mediates nuclear accumulation.小鼠沙杜蛋白高度保守的N端（RXXX）8基序介导核内积聚。
Biochim Biophys Acta. 2013 May;1833(5):1199-211. doi: 10.1016/j.bbamcr.2013.01.020. Epub 2013 Jan 27.
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Real time quaking-induced conversion analysis of cerebrospinal fluid in sporadic Creutzfeldt-Jakob disease.实时液滴式数字 PCR 检测分析散发性克雅病患者脑脊液中的朊病毒。
Ann Neurol. 2012 Aug;72(2):278-85. doi: 10.1002/ana.23589.
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Multiple substitutions of methionine 129 in human prion protein reveal its importance in the amyloid fibrillation pathway.多种人朊蛋白第 129 位蛋氨酸的取代揭示了其在淀粉样纤维形成途径中的重要性。
J Biol Chem. 2012 Jul 27;287(31):25975-84. doi: 10.1074/jbc.M112.372136. Epub 2012 Jun 5.
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Knockout of the prion protein (PrP)-like Sprn gene does not produce embryonic lethality in combination with PrP(C)-deficiency.敲除朊病毒蛋白样 Sprn 基因与 PrP(C)-缺陷并不产生胚胎致死性。
Proc Natl Acad Sci U S A. 2012 Jun 5;109(23):9035-40. doi: 10.1073/pnas.1202130109. Epub 2012 May 22.
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Efficient treatment of solvation shells in 3D molecular theory of solvation.高效处理 3D 分子溶剂化理论中的溶剂化壳层。
J Comput Chem. 2012 Jun 30;33(17):1478-94. doi: 10.1002/jcc.22974. Epub 2012 Apr 20.
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Exploring the essential collective dynamics of interacting proteins: application to prion protein dimers.探索相互作用蛋白的基本集体动力学：在朊病毒蛋白二聚体中的应用。
Proteins. 2012 Jul;80(7):1847-65. doi: 10.1002/prot.24082. Epub 2012 May 10.
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