Gao Xiaofeng, Wang Huan, Chen Hui
Fujian Provincial Cardiovascular Disease Institute, Fujian Medical University, Fuzhou, Fujian, P.R. China.
Ningde Hospital affiliated to Fujian Medical University,13 Mingdong East Road, Ningde, Fujian 352100, P.R. China.
Pharmacogenomics. 2024 May 31:1-9. doi: 10.2217/pgs-2017-0203.
To explore the effect of (100C > T) and 1165 G > C polymorphisms on heart rate of post-PCI (percutaneous coronary intervention) patients treated with metoprolol succinate sustained-release tablets. A total of 756 inpatients with metoprolol succinate sustained-release tablets were selected and the genotypes of and 1165G > C were detected in 319 patients using gene chip detection. The target heart rate was defined as a resting heart rate < 70 beats/min. Clinical data were collected. A total of 319 inpatients were enrolled in the study. The mutant allele frequencies of and were 57.21 and 69.44%, respectively. Whatever the dose of metoprolol, the heart rates were lower in patients with homozygous mutation of than those with heterozygous mutation and wild-type (p < 0.05). Nevertheless, this effect was not seen between different genotypes of . Logistic regression analysis showed that the dose of metoprolol and the genotypes of were predictors of heart rate <70 beats/min in these patients. Further multivariate analysis indicated that patients with homozygous mutation had better control of heart rates compared with those with wild-type and heterozygous mutation of genotypes (all: p < 0.001). polymorphisms were associated with the heart rate of post-PCI patients treated with metoprolol succinate sustained-release tablets.
探讨（100C>T）和1165G>C基因多态性对琥珀酸美托洛尔缓释片治疗经皮冠状动脉介入治疗（PCI）术后患者心率的影响。共选取756例服用琥珀酸美托洛尔缓释片的住院患者，采用基因芯片检测技术对其中319例患者检测（100C>T）和1165G>C的基因型。将目标心率定义为静息心率<70次/分钟，并收集临床资料。共有319例住院患者纳入本研究。（100C>T）和1165G>C的突变等位基因频率分别为57.21%和69.44%。无论美托洛尔剂量如何，（100C>T）纯合突变患者的心率低于杂合突变和野生型患者（p<0.05）。然而，1165G>C不同基因型之间未观察到这种效应。Logistic回归分析显示，美托洛尔剂量和（100C>T）基因型是这些患者心率<70次/分钟的预测因素。进一步多因素分析表明，与（100C>T）基因型野生型和杂合突变患者相比，纯合突变患者心率控制更佳（均为：p<0.001）。（100C>T）基因多态性与琥珀酸美托洛尔缓释片治疗PCI术后患者的心率有关。
