Department of Obstetric and Gynaecology, Xiangya Hospital of Central South University, Changsha, China.
Department of Obstetric and Gynaecology, Xiangya Hospital of Central South University, Changsha, China.
Biomed Pharmacother. 2018 Jan;97:543-550. doi: 10.1016/j.biopha.2017.10.083. Epub 2017 Nov 6.
Among the first found cancer-related long non-coding RNAs (lncRNAs), MALAT1 is one that involves in the development and progression of some tumors. MALAT1 can be aberrantly expressed in hepatocellular carcinoma, cervical, breast, ovarian cancers, as well as colorectal cancer. The paper aims to make certain the function of MALAT1 in human choriocarcinoma cell lines by investigating the detailed effects and molecular mechanisms. Being specifically upregulated in choriocarcinoma cell lines, the under-researched lncRNA-MALAT1 promoted choriocarcinoma cell growth by targeting miR-218. After MALAT1 knockdown, proliferation of human choriocarcinoma cell in vitro was dramatically hindered, and the tumor size in vivo was reduced. What is more, miR-218-mediated Fbxw8 regulation was required for MALAT1-induced choriocarcinoma cell proliferation. Taken together, MALAT1 might promote choriocarcinoma tumor growth through miR-218-mediated Fbxw8 regulation. According to our data, MALAT1 might be an oncogenic lncRNA that promoted choriocarcinoma proliferation and could be therapeutically targeted in human choriocarcinoma.
在最初发现的与癌症相关的长非编码 RNA（lncRNA）中，MALAT1 是一种参与某些肿瘤发生和发展的 lncRNA。MALAT1 在肝癌、宫颈癌、乳腺癌、卵巢癌以及结直肠癌中可以异常表达。本文旨在通过研究其详细的作用机制和分子机制，确定 MALAT1 在人绒癌细胞系中的功能。在绒癌细胞系中特异性上调的未被充分研究的 lncRNA-MALAT1 通过靶向 miR-218 促进绒癌细胞生长。敲低 MALAT1 后，体外人绒癌细胞的增殖明显受到抑制，体内肿瘤体积减小。此外，MALAT1 诱导的绒癌细胞增殖需要 miR-218 介导的 Fbxw8 调节。总之，MALAT1 可能通过 miR-218 介导的 Fbxw8 调节促进绒癌肿瘤生长。根据我们的数据，MALAT1 可能是一种致癌 lncRNA，促进绒癌增殖，可作为人绒癌的治疗靶点。
