在背景下的检测：D-二聚体。
A Test in Context: D-Dimer.
机构信息
Department of Medicine, McMaster University, Hamilton, Ontario, Canada; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada; Thrombosis and Atherosclerosis Research Institute, McMaster University, Hamilton, Ontario, Canada.
Department of Medicine, McMaster University, Hamilton, Ontario, Canada; Thrombosis and Atherosclerosis Research Institute, McMaster University, Hamilton, Ontario, Canada.
出版信息
J Am Coll Cardiol. 2017 Nov 7;70(19):2411-2420. doi: 10.1016/j.jacc.2017.09.024.
D-dimer is a soluble fibrin degradation product that results from ordered breakdown of thrombi by the fibrinolytic system. Numerous studies have shown that D-dimer serves as a valuable marker of activation of coagulation and fibrinolysis. Consequently, D-dimer has been extensively investigated for the diagnosis of venous thromboembolism (VTE) and is used routinely for this indication. In addition, D-dimer has been evaluated for determining the optimal duration of anticoagulation in VTE patients, for diagnosing and monitoring disseminated intravascular coagulation, and as an aid in the identification of medical patients at high risk for VTE. Thus, quantification of D-dimer levels serves an important role in guiding therapy. This review: 1) describes how D-dimer is generated; 2) reviews the assays used for its detection; and 3) discusses the role of D-dimer determination in these various conditions.
D-二聚体是一种可溶性纤维蛋白降解产物，来源于纤维蛋白溶解系统对血栓的有序分解。大量研究表明，D-二聚体可作为凝血和纤维蛋白溶解激活的有价值的标志物。因此，D-二聚体已被广泛研究用于诊断静脉血栓栓塞症（VTE），并常规用于该适应证。此外，D-二聚体已被评估用于确定 VTE 患者抗凝的最佳持续时间，用于诊断和监测弥漫性血管内凝血，并作为识别 VTE 高危医疗患者的辅助手段。因此，D-二聚体水平的定量在指导治疗中起着重要作用。本综述：1）描述了 D-二聚体的产生方式；2）回顾了用于其检测的检测方法；3）讨论了 D-二聚体测定在这些不同情况下的作用。
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