Vav1：癌症的朋友与敌人。
Vav1: Friend and Foe of Cancer.
机构信息
Division of Experimental Hematology and Cancer Biology, Children's Hospital Medical Center, University of Cincinnati, Cincinnati, OH 45229, USA.
Division of Experimental Hematology and Cancer Biology, Children's Hospital Medical Center, University of Cincinnati, Cincinnati, OH 45229, USA.
出版信息
Trends Cell Biol. 2017 Dec;27(12):879-880. doi: 10.1016/j.tcb.2017.10.004. Epub 2017 Oct 30.
Abstract
A recent study shows that the protumorigenic guanine nucleotide exchange factor (GEF) Vav1 functions as a tumor suppressor in T cell acute lymphoblastic leukemia (T-ALL) through its ability to complex with the Cbl-b ubiquitin ligase and the intracellular domain of Notch1 (ICN1) and to promote ICN1 degradation. Vav1can act as a double-edged sword in tumorigenesis.
摘要
最近的一项研究表明，致癌鸟嘌呤核苷酸交换因子（GEF）Vav1 通过与 Cbl-b 泛素连接酶和 Notch1 的细胞内结构域（ICN1）结合并促进 ICN1 降解，在 T 细胞急性淋巴细胞白血病（T-ALL）中作为肿瘤抑制因子发挥作用。Vav1 在肿瘤发生中可以起到双刃剑的作用。
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