抗 HIV 被动免疫：新武器在兵工厂。
Anti-HIV Passive Immunization: New Weapons in the Arsenal.
机构信息
Department of Virology and Immunology, Texas Biomedical Research Institute, San Antonio, TX, USA; Southwest National Primate Research Center, San Antonio, TX, USA.
出版信息
Trends Microbiol. 2017 Dec;25(12):954-956. doi: 10.1016/j.tim.2017.10.006. Epub 2017 Oct 30.
Abstract
Anti-HIV passive immunization with human neutralizing monoclonal antibodies (nmAbs) has made exciting gains: (i) identification of the HIV envelope V2 apex as a new in vivo protective epitope, (ii) a novel clade C SHIV for challenge studies, and (iii) a highly protective, trispecific nmAb. Potent, broad-spectrum protection by nmAbs holds promise.
摘要
抗 HIV 被动免疫用人源中和单克隆抗体（nmAbs）取得了令人兴奋的进展：（i）鉴定出 HIV 包膜 V2 顶点作为新的体内保护性表位，（ii）一种新的用于挑战研究的 clade C SHIV，和（iii）一种高度保护性的三特异性 nmAb。nmAbs 具有强大的广谱保护作用。
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