INSERM UMRS 1138, Sorbonne Université, Centre de Recherche des Cordeliers, 75006, Paris, France; Sorbonne Paris Cité, Université Paris Descartes, Université Paris Diderot, Centre de Recherche des Cordeliers, 75006, Paris, France.
INSERM UMRS 1138, Sorbonne Université, Centre de Recherche des Cordeliers, 75006, Paris, France; Sorbonne Paris Cité, Université Paris Descartes, Université Paris Diderot, Centre de Recherche des Cordeliers, 75006, Paris, France; Assistance Publique-Hôpitaux de Paris, Department of Endocrinology, Nutrition, and Diabetes, Paris, France; Institute of Cardiometabolism and Nutrition, ICAN, Assistance Publique-Hôpitaux de Paris, Pitié-Salpêtrière hospital, Paris, France.
Biochimie. 2017 Dec;143:37-41. doi: 10.1016/j.biochi.2017.10.019. Epub 2017 Oct 31.
Non Alcoholic Fatty Liver Disease (NAFLD) is currently the most common chronic liver disease in the world, encompassing various conditions ranging from simple steatosis, steatohepatitis, to fibrosis and cirrhosis. The association between NAFLD and Type 2 Diabetes (T2D) is strong and complex, given that the prevalence of NAFLD is particularly high in individuals with Type 2 Diabetes. In fact, insulin resistance occurring in this metabolic disease can promote NAFLD development, and vice versa, NAFLD can enhance insulin resistance. In this review, we focus on the mechanisms linking NAFLD and T2D, including fatty acid accumulation, inflammation, oxidative stress etc. We also discuss about situations showing a dissociation between steatosis and insulin resistance, in order to provide new insights for NAFLD therapeutic targets.
非酒精性脂肪性肝病（NAFLD）是目前世界上最常见的慢性肝病，涵盖了从单纯性脂肪变性、脂肪性肝炎到纤维化和肝硬化等各种疾病。NAFLD 与 2 型糖尿病（T2D）之间存在着密切而复杂的关联，因为 2 型糖尿病患者中 NAFLD 的患病率特别高。事实上，这种代谢性疾病中发生的胰岛素抵抗可以促进 NAFLD 的发展，反之亦然，NAFLD 也可以增强胰岛素抵抗。在这篇综述中，我们重点讨论了将 NAFLD 和 T2D 联系起来的机制，包括脂肪酸积累、炎症、氧化应激等。我们还讨论了在脂肪变性和胰岛素抵抗之间出现脱偶联的情况，以期为 NAFLD 的治疗靶点提供新的见解。
