在7位带有取代肼的丝裂霉素C类似物。合成、光谱性质及生物活性。

Mitomycin C analogues with a substituted hydrazine at position 7. Synthesis, spectral properties, and biological activity.

作者信息

Sawhney K N, Kohn H

机构信息

Department of Chemistry, University of Houston, Texas 77204-5641.

出版信息

J Med Chem. 1989 Jan;32(1):248-52. doi: 10.1021/jm00121a044.

DOI:10.1021/jm00121a044

PMID:2909738

Abstract

A select number of mitomycin C derivatives with a substituted hydrazine group at position 7 were synthesized and tested for antineoplastic activity by using an in vivo test with murine P388 leukemia. Several of the adducts displayed activity comparable to that of mitomycin C. The X-ray-determined crystal structure of one of the derivatives (3f) is reported.

摘要

合成了若干在7位带有取代肼基的丝裂霉素C衍生物，并通过小鼠P388白血病体内试验测试其抗肿瘤活性。其中几种加合物显示出与丝裂霉素C相当的活性。报道了其中一种衍生物（3f）的X射线测定晶体结构。