John J. McGrath, MD, PhD, Queensland Centre for Mental Health Research, and Queensland Brain Institute, University of Queensland, and National Centre for Register-based Research, Aarhus BSS, Aarhus University, Aarhus, Denmark; Sukanta Saha, PhD, Queensland Centre for Mental Health Research, and Queensland Brain Institute, University of Queensland, Australia; Carmen C. W. Lim, MSc, Queensland Brain Institute, The University of Queensland, St. Lucia, Queensland, Australia; Sergio Aguilar-Gaxiola, MD, PhD, Center for Reducing Health Disparities, UC Davis Health System, Sacramento, California, USA; Jordi Alonso, MD, PhD, Health Services Research Unit, IMIM-Hospital del Mar Medical Research Institute, Barcelona, Spain, Pompeu Fabra University (UPF), Barcelona, Spain and CIBER en Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain; Laura H. Andrade, MD, PhD, Section of Psychiatric Epidemiology - LIM 23, Institute of Psychiatry, University of São Paulo Medical School, São Paulo, Brazil; Evelyn J. Bromet, PhD, Department of Psychiatry, Stony Brook University School of Medicine, Stony Brook, New York, USA; Ronny Bruffaerts, PhD, Universitair Psychiatrisch Centrum - Katholieke Universiteit Leuven (UPC-KUL), Campus Gasthuisberg, Leuven, Belgium; José M. Caldas de Almeida, MD, PhD, Chronic Diseases Research Center (CEDOC) and Department of Mental Health, Faculdade de Ciências Médicas, Universidade Nova de Lisboa, (Campo dos Mártires da Pátria), Lisbon, Portugal; Graça Cardoso, MD, PhD, Lisbon Institute of Global Mental Health and Chronic Diseases Research Center (CEDOC), Nova Medical School, Universidade Nova de Lisboa, Lisboa, Portugal; Giovanni de Girolamo, MD, Unit of Epidemiological and Evaluation Psychiatry, Istituti di Ricovero e Cura a Carattere Scientifico (IRCCS) - St. John of God Clinical Research Centre, Brescia, Italy; John Fayyad, MD, Institute for Development, Research, Advocacy & Applied Care (IDRAAC), Beirut, Lebanon; Silvia Florescu, MD, PhD, National School of Public Health, Management and Professional Development, Bucharest, Romania; Oye Gureje, MD, DSc, FRCPsych, Department of Psychiatry, University College Hospital, Ibadan, Nigeria; Josep M. Haro, MD, PhD, Parc Sanitari Sant Joan de Déu, CIBERSAM, Universitat de Barcelona, Barcelona, Spain; Norito Kawakami, MD, DMSc, Department of Mental Health, School of Public Health, The University of Tokyo, Tokyo, Japan; Karestan C. Koenen, PhD, Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA; Viviane Kovess-Masfety, MD, PhD, Ecole des Hautes Etudes en Santé Publique (EHESP), EA 4057 Paris Descartes University, Paris, France; Sing Lee, MBBS, Department of Psychiatry, Chinese University of Hong Kong, Tai Po, Hong Kong; Jean-Pierre Lepine, MD, Hôpital Lariboisière- Fernand widal, Assistance Publique Hôpitaux de Paris, Universités Paris Descartes-Paris Diderot and INSERM UMR-S 1144, Paris, France; Katie A. McLaughlin, PhD, Department of Psychology, University of Washington, Seattle, Washington, USA; Maria E. Medina-Mora, PhD, National Institute of Psychiatry Ramón de la Fuente, Mexico City, Mexico; Fernando Navarro-Mateu, MD, PhD, IMIB-Arrixaca, CIBERESP-Murcia, Subdirección General de Salud Mental y Asistencia Psiquiátrica, Servicio Murciano delusional experiences Salud, El Palmar (Murcia), Spain; Akin Ojagbemi, PhD, College of Medicine, University of Ibadan; University College Hospital, Ibadan, Nigeria; Jose Posada-villa, MD, Colegio Mayor de Cundinamarca University, Faculty of Social Sciences, Bogota, Colombia; Nancy Sampson, BA, Department of Health Care Policy, Harvard Medical School, Boston, Massachusetts, USA; Kate M. Scott, PhD, Department of Psychological Medicine, University of Otago, Dunedin, Otago, New Zealand; Hisateru Tachimori, PhD, National Institute of Mental Health, National Center for Neurology and Psychiatry, Tokyo, Japan; Margreet ten Have, PhD, Trimbos-Instituut, Netherlands Institute of Mental Health and Addiction, Netherlands; Kenneth S. Kendler, MD, Department of Psychiatry, Virginia Commonwealth University, USA; Ronald C. Kessler, PhD, Department of Health Care Policy, Harvard Medical School, Boston, Massachusetts, USA
John J. McGrath, MD, PhD, Queensland Centre for Mental Health Research, and Queensland Brain Institute, University of Queensland, and National Centre for Register-based Research, Aarhus BSS, Aarhus University, Aarhus, Denmark; Sukanta Saha, PhD, Queensland Centre for Mental Health Research, and Queensland Brain Institute, University of Queensland, Australia; Carmen C. W. Lim, MSc, Queensland Brain Institute, The University of Queensland, St. Lucia, Queensland, Australia; Sergio Aguilar-Gaxiola, MD, PhD, Center for Reducing Health Disparities, UC Davis Health System, Sacramento, California, USA; Jordi Alonso, MD, PhD, Health Services Research Unit, IMIM-Hospital del Mar Medical Research Institute, Barcelona, Spain, Pompeu Fabra University (UPF), Barcelona, Spain and CIBER en Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain; Laura H. Andrade, MD, PhD, Section of Psychiatric Epidemiology - LIM 23, Institute of Psychiatry, University of São Paulo Medical School, São Paulo, Brazil; Evelyn J. Bromet, PhD, Department of Psychiatry, Stony Brook University School of Medicine, Stony Brook, New York, USA; Ronny Bruffaerts, PhD, Universitair Psychiatrisch Centrum - Katholieke Universiteit Leuven (UPC-KUL), Campus Gasthuisberg, Leuven, Belgium; José M. Caldas de Almeida, MD, PhD, Chronic Diseases Research Center (CEDOC) and Department of Mental Health, Faculdade de Ciências Médicas, Universidade Nova de Lisboa, (Campo dos Mártires da Pátria), Lisbon, Portugal; Graça Cardoso, MD, PhD, Lisbon Institute of Global Mental Health and Chronic Diseases Research Center (CEDOC), Nova Medical School, Universidade Nova de Lisboa, Lisboa, Portugal; Giovanni de Girolamo, MD, Unit of Epidemiological and Evaluation Psychiatry, Istituti di Ricovero e Cura a Carattere Scientifico (IRCCS) - St. John of God Clinical Research Centre, Brescia, Italy; John Fayyad, MD, Institute for Development, Research, Advocacy & Applied Care (IDRAAC), Beirut, Lebanon; Silvia Florescu, MD, PhD, National School of Public Health, Management and Professional Development, Bucharest, Romania; Oye Gureje, MD, DSc, FRCPsych, Department of Psychiatry, University College Hospital, Ibadan, Nigeria; Josep M. Haro, MD, PhD, Parc Sanitari Sant Joan de Déu, CIBERSAM, Universitat de Barcelona, Barcelona, Spain; Norito Kawakami, MD, DMSc, Department of Mental Health, School of Public Health, The University of Tokyo, Tokyo, Japan; Karestan C. Koenen, PhD, Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA; Viviane Kovess-Masfety, MD, PhD, Ecole des Hautes Etudes en Santé Publique (EHESP), EA 4057 Paris Descartes University, Paris, France; Sing Lee, MBBS, Department of Psychiatry, Chinese University of Hong Kong, Tai Po, Hong Kong; Jean-Pierre Lepine, MD, Hôpital Lariboisière- Fernand widal, Assistance Publique Hôpitaux de Paris, Universités Paris Descartes-Paris Diderot and INSERM UMR-S 1144, Paris, France; Katie A. McLaughlin, PhD, Department of Psychology, University of Washington, Seattle, Washington, USA; Maria E. Medina-Mora, PhD, National Institute of Psychiatry Ramón de la Fuente, Mexico City, Mexico; Fernando Navarro-Mateu, MD, PhD, IMIB-Arrixaca, CIBERESP-Murcia, Subdirección General de Salud Mental y Asistencia Psiquiátrica, Servicio Murciano delusional experiences Salud, El Palmar (Murcia), Spain; Akin Ojagbemi, PhD, College of Medicine, University of Ibadan; University College Hospital, Ibadan, Nigeria; Jose Posada-villa, MD, Colegio Mayor de Cundinamarca University, Faculty of Social Sciences, Bogota, Colombia; Nancy Sampson, BA, Department of Health Care Policy, Harvard Medical School, Boston, Massachusetts, USA; Kate M. Scott, PhD, Department of Psychological Medicine, University of Otago, Dunedin, Otago, New Zealand; Hisateru Tachimori, PhD, National Institute of Mental Health, National Center for Neurology and Psychiatry, Tokyo, Japan; Margreet ten Have, PhD, Trimbos-Instituut, Netherlands Institute of Mental Health and Addiction, Netherlands; Kenneth S. Kendler, MD, Department of Psychiatry, Virginia Commonwealth University, USA; Ronald C. Kessler, PhD, Department of Health Care Policy, Harvard Medical School, Boston, Massachusetts, USA.
Br J Psychiatry. 2017 Dec;211(6):373-380. doi: 10.1192/bjp.bp.117.205955. Epub 2017 Nov 2.
Traumatic events are associated with increased risk of psychotic experiences, but it is unclear whether this association is explained by mental disorders prior to psychotic experience onset.To investigate the associations between traumatic events and subsequent psychotic experience onset after adjusting for post-traumatic stress disorder and other mental disorders.We assessed 29 traumatic event types and psychotic experiences from the World Mental Health surveys and examined the associations of traumatic events with subsequent psychotic experience onset with and without adjustments for mental disorders.Respondents with any traumatic events had three times the odds of other respondents of subsequently developing psychotic experiences (OR = 3.1, 95% CI 2.7-3.7), with variability in strength of association across traumatic event types. These associations persisted after adjustment for mental disorders.Exposure to traumatic events predicts subsequent onset of psychotic experiences even after adjusting for comorbid mental disorders.
创伤性事件与精神病体验风险增加有关，但目前尚不清楚这种关联是否可以用精神病体验发病前的精神障碍来解释。为了调查在调整创伤后应激障碍和其他精神障碍后，创伤性事件与随后精神病体验发病之间的关联。我们评估了世界心理健康调查中的 29 种创伤性事件类型和精神病体验，并检查了创伤性事件与随后精神病体验发病之间的关联，包括和不包括精神障碍的调整。有任何创伤性事件的受访者随后出现精神病体验的可能性是其他受访者的三倍（OR = 3.1，95%CI 2.7-3.7），不同类型的创伤性事件的关联强度存在差异。这些关联在调整精神障碍后仍然存在。即使在调整了共病精神障碍后，暴露于创伤性事件也预示着随后精神病体验的发作。
