Abushanab E, Sarma M S
Department of Medicinal Chemistry, University of Rhode Island, Kingston 02118.
J Med Chem. 1989 Jan;32(1):76-9. doi: 10.1021/jm00121a016.
1',2'-seco-2',3'-Dideoxycytidine (12), -guanosine (14), -adenosine (16), and -inosine (18) were prepared from (R)-benzylglycidol as potential anti-HIV agents. When compared to ddAdo in protecting ATH8 cells, they were found to be inactive.
1',2'-裂环-2',3'-双脱氧胞苷(12)、-鸟苷(14)、-腺苷(16)和-肌苷(18)由(R)-苄基缩水甘油制备而成,作为潜在的抗HIV药物。与双脱氧腺苷在保护ATH8细胞方面进行比较时,发现它们没有活性。