Landstrom J, Osgood G, Young S C
Department of General Surgery, Providence Hospital, Southfield, Michigan.
J Surg Oncol. 1989 Jan;40(1):1-3. doi: 10.1002/jso.2930400103.
A series of 211 women underwent 211 preoperative needle localizations of nonpalpable breast lesions. All mammographic, operative, and pathological data were reviewed. Carcinoma occurred in 10%. Seventeen (81%) were invasive, and four (19%) were noninvasive. Forty-three percent of the cancers were minimal carcinoma (in situ or an invasive cancer measuring less than 5 mm in size with negative axillary nodes), and 48% were less than 1 cm. Overall, metastasis to axillary lymph nodes occurred in 10%. The mammographic findings of microcalcifications occurred in 81% of the malignant group and in 33% of the benign group. The combination of microcalcifications in association with an irregular density was only found in the malignant group. We conclude that 1) needle localization enables the early detection of stage I breast carcinoma and 2) the mammographic findings of microcalcifications in association with an irregular density occur only with malignancy in this series.
211名女性接受了211次术前对不可触及乳腺病变的针定位。回顾了所有乳房X线摄影、手术和病理数据。10%的患者发生癌变。其中17例（81%）为浸润性癌，4例（19%）为非浸润性癌。43%的癌症为微小癌（原位癌或腋窝淋巴结阴性、大小小于5mm的浸润性癌），48%的癌症小于1cm。总体而言，10%的患者出现腋窝淋巴结转移。乳房X线摄影显示微钙化在恶性组中的发生率为81%，在良性组中的发生率为33%。微钙化与不规则密度相结合仅在恶性组中发现。我们得出结论：1）针定位能够早期发现I期乳腺癌；2）在本系列中，微钙化与不规则密度的乳房X线摄影表现仅见于恶性病变。
