Department of Pediatrics, Graduate School, Kyung Hee University, Seoul, Republic of Korea.
Department of Pediatrics, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam, Republic of Korea.
Biomed Res Int. 2017;2017:3793679. doi: 10.1155/2017/3793679. Epub 2017 Sep 20.
The purpose of this study was to investigate the effects of home remodeling and food allergy (FA) on the development of atopic dermatitis (AD) in children.
The Modified International Study of Asthma and Allergies in Childhood questionnaire was used to survey 4,111 children recruited from 3 kindergartens and 6 elementary schools from Seongnam, Korea. Participants' parents agreed for them to participate in physical examinations, skin prick tests, and blood tests.
Home remodeling in the past 12 months (adjusted odds ratio [aOR] 3.40, = 0.006), lifetime diagnosis of FA (aOR 3.95, < 0.001), parental history of AD (aOR 2.67, = 0.001), and FA (aOR 2.35, = 0.004) were independent risk factors for lifetime diagnosis of AD ever. When history of home remodeling and FA were combined, the risk for moderate-to-severe AD by scoring atopic dermatitis (SCORAD) score increased (aOR, 7.19, = 0.011, for interaction = 0.034).
Home remodeling, lifetime diagnosis of FA, parental history of AD, and parental history of FA were independent risk factors for AD. In addition, we observed a synergistic interaction between home remodeling and FA in the risk of moderate-to-severe AD.
本研究旨在探讨家居装修和食物过敏（FA）对儿童特应性皮炎（AD）发展的影响。
使用改良的国际儿童哮喘和过敏研究问卷对韩国城南市 3 所幼儿园和 6 所小学的 4111 名儿童进行了调查。参与者的父母同意他们参加体检、皮肤点刺试验和血液检查。
过去 12 个月的家居装修（调整后的优势比[aOR]3.40，=0.006）、终身诊断的 FA（aOR 3.95，<0.001）、父母的 AD 病史（aOR 2.67，=0.001）和 FA（aOR 2.35，=0.004）是终身诊断 AD 的独立危险因素。当考虑家居装修和 FA 的历史时，根据特应性皮炎评分（SCORAD）评分，中重度 AD 的风险增加（aOR，7.19，=0.011，交互作用=0.034）。
家居装修、FA 的终身诊断、AD 的父母病史和 FA 的父母病史是 AD 的独立危险因素。此外，我们观察到家居装修和 FA 之间在中重度 AD 的风险上存在协同交互作用。
