Zhao Yan-Qing, Li Qing-Song, Xiang Min-Hong, Zhang Wei, Zhang Xing-Ru
The Affiliated Putuo Hospital of Shanghai University of Traditional Chinese Medicine, Shanghai 200062, China.
Zhongguo Zhong Yao Za Zhi. 2017 Jul;42(14):2796-2801. doi: 10.19540/j.cnki.cjcmm.20170523.003.
To investigate the distribution of traditional Chinese medicine (TCM) Syndromes of diabetic retinopathy and explore the correlation between various symptoms. Based on the literature in databases of China Journal Full-text Database (CNKI), Wanfang database, VIP network, China biomedical literature database (CBM) and PubMed, SPSS 20.0 and IBM SPSS Modeler 14.1 software were used to analyze the location of disease, symptoms, tongue and pulse, and syndrome type distribution through frequency statistics. In addition, association rule algorithm was used to explore the basic rules for underlying symptoms combinations of diabetic retinopathy. A total of 560 articles were retrieved, and a total of 240 articles met the inclusion and exclusion criteria. In these documents, 62 types of TCM syndromes were found, involving 9 820 cases, 201 symptoms, 29 tongue conditions, and 36 pulses conditions; the first two locations for the disease were liver and kidney. Then the association rule analysis of high frequency symptoms was used to dig out 15 groups of latent syndrome, and 3 underlying symptom combinations among high frequency symptoms, tongue conditions and pulse conditions. The results of the study showed that Qi and yin deficiency was most common for the diabetic retinopathy, and the location of the disease was closely related to liver and kidney. In addition, these high-frequency symptoms and tongue conditions, pulse conditions, and underlying symptom combinations can occur as main symptoms at diagnosis, providing reference for us to study the epidemiology of PRO scale of the disease. They can also increase the weight of these symptoms directly as the main symptoms, which can be also used as an alternative entry pool for TCM syndrome diagnostic scale, laying foundation for the construction and optimization of TCM symptom database of diabetic retinopathy.
探讨糖尿病视网膜病变中医证候分布规律，探索各症状间的相关性。通过检索中国知网（CNKI）、万方数据库、维普网、中国生物医学文献数据库（CBM）及PubMed数据库中的文献，运用SPSS 20.0和IBM SPSS Modeler 14.1软件，采用频数统计分析糖尿病视网膜病变的病位、症状、舌象、脉象及证型分布情况。此外，运用关联规则算法探索糖尿病视网膜病变潜在症状组合的基本规律。共检索到560篇文献，其中240篇符合纳入与排除标准。这些文献中发现62种中医证候，涉及9820例患者，201种症状，29种舌象，36种脉象；病位在前两位的是肝和肾。然后对高频症状进行关联规则分析，挖掘出15组潜在证型，以及高频症状、舌象、脉象间的3种潜在症状组合。研究结果表明，糖尿病视网膜病变以气阴两虚最为常见，病位与肝、肾密切相关。此外，这些高频症状、舌象、脉象及潜在症状组合可作为诊断时的主要症状出现，为研究该病PRO量表的流行病学提供参考。还可直接增加这些症状作为主要症状的权重，也可作为中医证候诊断量表的备选条目库，为糖尿病视网膜病变中医症状数据库的构建与优化奠定基础。
