Ma Zu-Xia, Hu Guo-Hua
1 Department of Otorhinolaryngology, The First People's Hospital of Zunyi, Zunyi, China.
2 Department of Otorhinolaryngology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
J Int Med Res. 2017 Dec;45(6):1939-1948. doi: 10.1177/0300060517715167. Epub 2017 Nov 3.
Objectives The aim of this study was to evaluate the impact of surgery and different implant materials on subjective outcomes in patients with empty nose syndrome (ENS). Methods Postsurgical outcomes were assessed in a meta-analysis of patients with ENS who underwent treatment with different implants. Results We identified 122 relevant studies, and 6 were included in the meta-analysis (4 prospective trials and 2 randomized controlled trials). A significant difference was found between the preoperative and postoperative Sino-Nasal Outcome Test (SNOT) scores for different implants. With respect to implant materials, significant differences were observed between autografts/allografts (AG) and foreign material grafts (FGs). A subgroup analysis of different countries showed that more patients from China underwent surgical implant therapy than patients from other countries. Conclusions This meta-analysis suggests that surgery can improve the symptoms and SNOT scores of patients with ENS, AGs are more effective than FGs in patients with ENS, and that more patients from China undergo surgical implant therapy than patients from other countries.
目的 本研究旨在评估手术及不同植入材料对空鼻综合征（ENS）患者主观结局的影响。方法 对接受不同植入物治疗的ENS患者进行荟萃分析，评估术后结局。结果 我们确定了122项相关研究，其中6项纳入荟萃分析（4项前瞻性试验和2项随机对照试验）。不同植入物术前和术后鼻鼻窦结局测试（SNOT）评分存在显著差异。关于植入材料，自体移植物/同种异体移植物（AG）和异体材料移植物（FG）之间存在显著差异。不同国家的亚组分析表明，接受手术植入治疗的中国患者比其他国家的患者更多。结论 这项荟萃分析表明，手术可改善ENS患者的症状和SNOT评分，AG对ENS患者比FG更有效，且接受手术植入治疗的中国患者比其他国家的患者更多。
