生长分化因子15作为急性冠脉综合征后长期随访中慢性心力衰竭进展的预后标志物
GROWTH DIFFERENTIATION FACTOR 15 AS A PROGNOSTIC MARKER OF CHRONIC HEART FAILURE PROGRESSION IN LONG-TERM FOLLOW-UP AFTER ACUTE CORONARY SYNDROME.
作者信息
Kopytsya M, Vyshnevska I, Protsenko O, Barahmeh H
机构信息
GI «L.T. Malaya Therapy National Institute of National Academy of Medical Science of Ukraine», Kharkiv; V.N. Karazin Kharkiv National University, Kharkiv, Ukraine.
出版信息
Georgian Med News. 2017 Oct(271):61-66.
Acute coronary syndrome remains a significant problem for cardiologists. Despite improved therapy, mortality remains extremely high once CHF becomes symptomatic. Multimarker approach in cardiovascular risk prediction was proved as the most effective tool. One of the promising biomarkers is a stress-induced marker growth differentiation factor 15 (GDF-15). Purpose of the study was to improve stratification methods of CHF progression risk as a complication of ACS by studying levels of GDF-15. In our study we showed association between high level of GDF-15, determined at the first 24 hours after ACS, and CHF progression after 12 months.
急性冠状动脉综合征仍然是心脏病专家面临的一个重大问题。尽管治疗方法有所改进，但一旦心力衰竭出现症状，死亡率仍然极高。心血管风险预测中的多标志物方法被证明是最有效的工具。一种有前景的生物标志物是应激诱导标志物生长分化因子15（GDF-15）。本研究的目的是通过研究GDF-15水平来改进作为急性冠状动脉综合征并发症的心力衰竭进展风险分层方法。在我们的研究中，我们发现急性冠状动脉综合征后最初24小时测定的高水平GDF-15与12个月后的心力衰竭进展之间存在关联。
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