Khalifeh Hassan K, Mourad Youmna M, Chamoun Cynthia T
Department of Pediatric Hematology Oncology, Zahraa University Hospital, Beirut 1131, Lebanon.
Department of Pediatric Hematology Oncology, Faculty of Medical Sciences, Lebanese University, Beirut 1131, Lebanon.
Children (Basel). 2017 Nov 3;4(11):94. doi: 10.3390/children4110094.
Autoimmune hemolytic anemia is a rare hematologic entity in children. Etiologies are mainly viruses or bacteria. We describe here a case of severe warm autoimmune hemolytic anemia (IgG- and C3d-positive direct antiglobulin test) in an immunocompetent 6-month-old infant with acute Cytomegalovirus infection that responded well to corticotherapy and intraveneous immunoglobulins without using blood component transfusion. This case demonstrates the importance of recognizing CMV in infantile Autoimmune Hemolytic Anemia, especially because hemolysis can be severe and lethal.
自身免疫性溶血性贫血在儿童中是一种罕见的血液学疾病。病因主要是病毒或细菌。我们在此描述一例6个月大免疫功能正常的婴儿，患有严重的温抗体型自身免疫性溶血性贫血（直接抗球蛋白试验IgG和C3d阳性），伴有急性巨细胞病毒感染，该患儿对皮质激素治疗和静脉注射免疫球蛋白反应良好，未进行血液成分输血。该病例表明了在婴儿自身免疫性溶血性贫血中识别巨细胞病毒的重要性，特别是因为溶血可能很严重甚至致命。
