婴儿巨细胞病毒相关的严重温抗体型自身免疫性溶血性贫血：一例报告
Infantile Cytomegalovirus-Associated Severe Warm Autoimmune Hemolytic Anemia: A Case Report.
作者信息
Khalifeh Hassan K, Mourad Youmna M, Chamoun Cynthia T
机构信息
Department of Pediatric Hematology Oncology, Zahraa University Hospital, Beirut 1131, Lebanon.
Department of Pediatric Hematology Oncology, Faculty of Medical Sciences, Lebanese University, Beirut 1131, Lebanon.
出版信息
Children (Basel). 2017 Nov 3;4(11):94. doi: 10.3390/children4110094.
Abstract
Autoimmune hemolytic anemia is a rare hematologic entity in children. Etiologies are mainly viruses or bacteria. We describe here a case of severe warm autoimmune hemolytic anemia (IgG- and C3d-positive direct antiglobulin test) in an immunocompetent 6-month-old infant with acute Cytomegalovirus infection that responded well to corticotherapy and intraveneous immunoglobulins without using blood component transfusion. This case demonstrates the importance of recognizing CMV in infantile Autoimmune Hemolytic Anemia, especially because hemolysis can be severe and lethal.
摘要
自身免疫性溶血性贫血在儿童中是一种罕见的血液学疾病。病因主要是病毒或细菌。我们在此描述一例6个月大免疫功能正常的婴儿，患有严重的温抗体型自身免疫性溶血性贫血（直接抗球蛋白试验IgG和C3d阳性），伴有急性巨细胞病毒感染，该患儿对皮质激素治疗和静脉注射免疫球蛋白反应良好，未进行血液成分输血。该病例表明了在婴儿自身免疫性溶血性贫血中识别巨细胞病毒的重要性，特别是因为溶血可能很严重甚至致命。
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本文引用的文献
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Transfus Med Hemother. 2015 Sep;42(5):317-24. doi: 10.1159/000440656. Epub 2015 Sep 11.
2
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Transfus Med Hemother. 2015 Sep;42(5):287-93. doi: 10.1159/000439002. Epub 2015 Sep 7.
3
Red blood cell destruction in autoimmune hemolytic anemia: role of complement and potential new targets for therapy.自身免疫性溶血性贫血中的红细胞破坏：补体的作用及潜在的新治疗靶点
Biomed Res Int. 2015;2015:363278. doi: 10.1155/2015/363278. Epub 2015 Jan 29.
4
A fetal hemolytic anemia in a child with cytomegalovirus infection.一名患有巨细胞病毒感染儿童的胎儿溶血性贫血。
Iran J Ped Hematol Oncol. 2014;4(2):78-83. Epub 2014 Apr 20.
5
A case of warm autoimmune haemolytic anaemia with intravascular haemolysis: a rare presentation.一例伴有血管内溶血的温抗体型自身免疫性溶血性贫血：一种罕见的表现。
Ceylon Med J. 2013 Dec;58(4):176-8. doi: 10.4038/cmj.v58i4.6312.
6
Abstracts of the 36th Annual Meeting of the Society of General Internal Medicine. April 24-27, 2013. Denver, Colorado, USA.美国内科医学学会第36届年会摘要。2013年4月24日至27日。美国科罗拉多州丹佛市。
J Gen Intern Med. 2013 Jun;28 Suppl 1(Suppl 1):S1-489. doi: 10.1007/s11606-013-2436-y.
7
Congenital cytomegalovirus infection: molecular mechanisms mediating viral pathogenesis.先天性巨细胞病毒感染：介导病毒发病机制的分子机制
Infect Disord Drug Targets. 2011 Oct;11(5):449-65. doi: 10.2174/187152611797636721.
8
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Int J Hematol. 2010 Sep;92(2):283-8. doi: 10.1007/s12185-010-0635-4. Epub 2010 Jul 17.
10
Severe cytomegalovirus infection in apparently immunocompetent patients: a systematic review.免疫功能正常患者的严重巨细胞病毒感染：一项系统评价
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