Zhu Boqian, Si Xinmin, Gong Yaoyao, Yan Gaoliang, Wang Dong, Qiao Yong, Liu Bo, Hou Jiantong, Tang Chengchun
Department of Cardiology, Zhongda Hospital, Southeast University, Nanjing, China.
Department of Gastroenterology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Oncotarget. 2017 Aug 23;8(44):77990-77998. doi: 10.18632/oncotarget.20400. eCollection 2017 Sep 29.
Previous epidemiological studies have suggested that genetic factors are more likely to influence the development of premature coronary artery disease (CAD) than disease in older patients. Several studies have evaluated the association between the G894T polymorphism located in an exon of endothelial nitric oxide synthase (eNOS) and the risk of premature CAD. However, the findings were inconsistent. Thus, we performed a meta-analysis to clarify the association; we conducted both overall and subgroup analyses. Odds ratios and 95% confidence interval were calculated to evaluate the association between the G894T polymorphism and the risk of premature CAD. Overall analysis revealed a significant association. Subgroup analysis in terms of ethnicity revealed a significant association, in all models evaluated, between the G894T polymorphism and susceptibility to premature CAD in mixed population. In contrast, no such association was evident in Caucasians and Asians. On further subgroup analysis based on the premature CAD subtypes, we found that the G894T polymorphism was correlated with premature myocardial infarction (MI) but not with premature CAD without MI. In conclusion, we confirmed that the eNOS G894T polymorphism is a risk factor for premature CAD, particularly in those suffering premature MI.
以往的流行病学研究表明，与老年患者的疾病相比，遗传因素更有可能影响早发性冠状动脉疾病（CAD）的发生发展。多项研究评估了位于内皮型一氧化氮合酶（eNOS）一个外显子上的G894T多态性与早发性CAD风险之间的关联。然而，研究结果并不一致。因此，我们进行了一项荟萃分析以阐明这种关联；我们进行了总体分析和亚组分析。计算比值比和95%置信区间以评估G894T多态性与早发性CAD风险之间的关联。总体分析显示存在显著关联。按种族进行的亚组分析显示，在所有评估模型中，G894T多态性与混合人群早发性CAD的易感性之间存在显著关联。相比之下，在白种人和亚洲人中未发现这种关联。基于早发性CAD亚型的进一步亚组分析发现，G894T多态性与早发性心肌梗死（MI）相关，但与无MI的早发性CAD无关。总之，我们证实eNOS G894T多态性是早发性CAD的一个危险因素，尤其是在那些患有早发性MI的患者中。
