Li Yan-yan
Department of Geriatrics, First Affiliated Hospital of Nanjing Medical University, China.
Intern Med. 2011;50(19):2099-106. doi: 10.2169/internalmedicine.50.5856. Epub 2011 Oct 1.
The endothelial nitric oxide synthase (eNOS) G894T gene polymorphism has been suggested to be linked to the risk of essential hypertension (EH), however the results are still debatable.
To assess the association between eNOS G894T gene polymorphism and EH, such electronic databases as Pubmed, Embase, Web of Science, China Biological Medicine Database (CBMD) and China National Knowledge Infrastructure (CNKI) were searched. The selection criteria were as follows: a) Evaluation of the association of eNOS G894T gene polymorphism and EH. b) EH diagnosis in compliance with EH diagnosis criteria of the World Health Organization (WHO) in 1999. c) The study results were in line with the Hardy-Weinberg equilibrium (HWE). In 23 separate studies with 11,248 subjects the relation between eNOS G894T gene polymorphism and EH was analyzed by current meta-analysis. Random effect model was used to calculate the pooled odds ratio (ORs) and its corresponding 95% confidence interval (95% CI).
In this eNOS G894T gene polymorphism and EH meta-analysis in the Chinese population, the distribution of T allele frequency was 0.154 for EH group and 0.128 for the control group. A significant association was found between G894T gene polymorphism and EH (p=0.0007). The pooled OR for the distribution frequency of T allele was 1.33 (95% CI:1.13-1.56, P(heterogeneity) <0.00001). In the stratified analysis by ethnicity, there was a significant association in Han subgroup (p=0.005). The pooled OR for the distribution frequency of T allele was 1.31 (95% CI:1.09-1.59, P(heterogeneity) <0.00001). No significant increased risk for EH was found in the non-Han subgroup (p=0.08).
In the current meta-analysis, T allele of eNOS G894T gene was suggested to be related to the increased risk of EH in the Chinese population, particularly in those of Han ethnicity.
内皮型一氧化氮合酶（eNOS）G894T基因多态性被认为与原发性高血压（EH）风险相关，但结果仍存在争议。
为评估eNOS G894T基因多态性与EH之间的关联，检索了PubMed、Embase、Web of Science、中国生物医学数据库（CBMD）和中国知网（CNKI）等电子数据库。选择标准如下：a）评估eNOS G894T基因多态性与EH的关联。b）EH诊断符合1999年世界卫生组织（WHO）的EH诊断标准。c）研究结果符合哈迪-温伯格平衡（HWE）。通过当前的荟萃分析，对23项涉及11248名受试者的独立研究中eNOS G894T基因多态性与EH的关系进行了分析。采用随机效应模型计算合并比值比（ORs）及其相应的95%置信区间（95%CI）。
在本次针对中国人群的eNOS G894T基因多态性与EH的荟萃分析中，EH组T等位基因频率分布为0.154，对照组为0.128。发现G894T基因多态性与EH之间存在显著关联（p = 0.0007）。T等位基因分布频率的合并OR为1.33（95%CI：1.13 - 1.56，P（异质性）<0.00001）。在按种族分层分析中，汉族亚组存在显著关联（p = 0.005）。T等位基因分布频率的合并OR为1.31（95%CI：1.09 - 1.59，P（异质性）<0.00001）。在非汉族亚组中未发现EH风险显著增加（p = 0.08）。
在当前的荟萃分析中，提示eNOS G894T基因的T等位基因与中国人群尤其是汉族人群中EH风险增加有关。
