Birnie Kimberly A, Prêle Cecilia M, Thompson Philip J, Badrian Bahareh, Mutsaers Steven E
Institute for Respiratory Health, Centre for Respiratory Health, Harry Perkins Institute of Medical Research, QEII Medical Centre, School of Biomedical Sciences, University of Western Australia, Perth, Western Australia, Australia.
Centre for Cell Therapy and Regenerative Medicine, Harry Perkins Institute of Medical Research, QEII Medical Centre, School of Biomedical Sciences, University of Western Australia, Perth, Western Australia, Australia.
Oncotarget. 2017 Aug 24;8(44):78193-78207. doi: 10.18632/oncotarget.20409. eCollection 2017 Sep 29.
Malignant mesothelioma is an aggressive and often fatal cancer associated with asbestos exposure. The disease originates in the mesothelial lining of the serosal cavities, most commonly affecting the pleura. Survival rates are low as diagnosis often occurs at an advanced stage and current treatments are limited. Identifying new diagnostic and therapeutic targets for mesothelioma remains a priority, particularly for the new wave of victims exposed to asbestos through do-it-yourself renovations and in countries where asbestos is still mined and used. Recent advances have demonstrated a biological role for the small but powerful gene regulators microRNA (miRNA) in mesothelioma. A number of potential therapeutic targets have been identified. MiRNA have also become popular as potential biomarkers for mesothelioma due to their stable expression in bodily fluid and tissues. In this review, we highlight the current challenges associated with the diagnosis and treatment of mesothelioma and discuss how targeting miRNA may improve diagnostic, prognostic and therapeutic approaches.
恶性间皮瘤是一种侵袭性且往往致命的癌症，与接触石棉有关。该疾病起源于浆膜腔的间皮内衬，最常累及胸膜。由于诊断通常在晚期才出现且目前的治疗方法有限，生存率较低。确定间皮瘤的新诊断和治疗靶点仍然是当务之急，特别是对于通过自己动手翻新接触石棉的新一波受害者以及仍在开采和使用石棉的国家而言。最近的进展表明，微小但强大的基因调节因子微小RNA（miRNA）在间皮瘤中具有生物学作用。已经确定了一些潜在的治疗靶点。由于miRNA在体液和组织中表达稳定，它们也已成为间皮瘤潜在的生物标志物。在本综述中，我们强调了与间皮瘤诊断和治疗相关的当前挑战，并讨论了靶向miRNA如何改善诊断、预后和治疗方法。
