Department of Psychiatry and Psychotherapy, Charité University Medicine Berlin, Campus Mitte, Berlin, Germany.
Department of Psychiatry and Psychotherapy, Charité University Medicine Berlin, Campus Mitte, Berlin, Germany.
J Psychiatr Res. 2018 Jan;96:203-208. doi: 10.1016/j.jpsychires.2017.10.002. Epub 2017 Oct 5.
Lithium augmentation (LA) of antidepressants is a first-line therapy in treatment-resistant depression. Immunomodulatory effects of lithium have been described. The cytokine hypothesis of depression postulates that cytokines play a key role in the pathophysiology of depression. Concordantly, it has been shown that proinflammatory cytokine serum levels decrease during antidepressant treatment. The aim of this study was to investigate changes in cytokine serum levels during LA. Serum concentrations of the cytokines interleukin (IL)-2, IL-4, IL-6, IL-8, IL-10, tumour necrosis factor alpha, interferon-gamma, granulocyte and monocyte colony stimulating factor were measured in a total of 95 acutely depressed patients before and after four weeks of LA. Changes in cytokine levels were corrected for the confounding factors severity of depression, treatment response, lithium serum level, gender, age and body mass index in a linear mixed-model analysis. We did not find a significant change in any of the measured cytokine serum levels during LA (p > 0.05). In conclusion, our study does not support the role of cytokine serum levels as a state marker in treatment of depression with LA.
锂盐增效治疗（LA）是治疗抵抗性抑郁症的一线疗法。已描述了锂的免疫调节作用。抑郁症的细胞因子假说假设细胞因子在抑郁症的病理生理学中起关键作用。一致地，已经表明抗抑郁治疗期间促炎细胞因子的血清水平降低。本研究旨在调查 LA 期间细胞因子血清水平的变化。在 LA 前后共测量了 95 例急性抑郁患者的血清细胞因子白细胞介素 (IL)-2、IL-4、IL-6、IL-8、IL-10、肿瘤坏死因子 α、干扰素-γ、粒细胞和单核细胞集落刺激因子的浓度。在线性混合模型分析中，通过校正混杂因素（抑郁严重程度、治疗反应、锂血清水平、性别、年龄和体重指数）来纠正细胞因子水平的变化。我们没有发现 LA 期间任何测量的细胞因子血清水平有显著变化（p>0.05）。总之，我们的研究不支持细胞因子血清水平作为 LA 治疗抑郁症的状态标志物的作用。
