Discipline of Obstetrics, Gynaecology and Neonatology, Sydney Medical School Nepean, University of Sydney, Nepean Hospital, Penrith, NSW 2750 Australia; Christopher Kohlenberg Department of Perinatal Ultrasound, Nepean Hospital, Penrith NSW 2750 Australia.
Discipline of Obstetrics, Gynaecology and Neonatology, Sydney Medical School Nepean, University of Sydney, Nepean Hospital, Penrith, NSW 2750 Australia; Medical Sonography, School of Health, Medical and Applied Science, Central Queensland University, Sydney, NSW 2000 Australia.
Obes Res Clin Pract. 2017 Nov-Dec;11(6):655-664. doi: 10.1016/j.orcp.2017.10.003.
Abdominal adiposity and subcutaneous fat (SF), an important endocrine organ for health outcomes, can be divided into two layers, superficial (SSAT) and deep subcutaneous adipose tissue (DSAT) each with a different histological and metabolic function. The aim was to investigate longitudinal changes in maternal abdominal SF thickness and its layers throughout pregnancy and post-partum within body mass index (BMI) categories.
A prospective longitudinal study of 214 women was performed measuring abdominal SF using ultrasound at 12-14(M1), 18-20(M2), 26-29(M3) and 33-36 weeks' gestation (M4) and 6-8 weeks post-partum. SF thickness (SFT), SSAT and DSAT were measured. A ratio of DSAT/SSAT (D/S) was calculated. Measurements were compared to baseline and BMI evaluating for interaction with changes over time.
Of the 214 women, 43.5%(93) were normal weight, 25.7%(55) overweight and 30.8%(66) obese. SFT and SSAT decreased from M1 to M4 for the overweight and obese whilst remaining stable for normal weight women. For all BMI categories SFT and SSAT increased post-partum. DSAT decreased significantly in the obese and overweight and increased significantly in the normal weight. Obese women had a higher D/S at M1 that decreased at M2 and remained constant to post-partum. D/S increased at M2 then decreased in the overweight. Normal weight women increased D/S at M2-M4.
The results indicate a difference in distribution and mobilisation of fat in SSAT, and DSAT abdominal subcutaneous compartments within the different BMI categories in pregnancy. Understanding how fat mobilises during pregnancy may be fundamental to understanding obesity related complications.
腹部肥胖和皮下脂肪（SF）是健康结果的重要内分泌器官，可分为两层，浅层（SSAT）和深层皮下脂肪组织（DSAT），具有不同的组织学和代谢功能。目的是研究在 BMI 类别内，整个怀孕期间和产后腹部 SF 厚度及其层的纵向变化。
对 214 名女性进行了一项前瞻性纵向研究，在 12-14 周（M1）、18-20 周（M2）、26-29 周（M3）和 33-36 周（M4）妊娠和产后 6-8 周使用超声测量腹部 SF。测量 SF 厚度（SFT）、SSAT 和 DSAT。计算 DSAT/SSAT（D/S）的比值。比较基线和 BMI 以评估与随时间变化的相互作用。
在 214 名女性中，43.5%（93 名）为正常体重，25.7%（55 名）为超重，30.8%（66 名）为肥胖。超重和肥胖女性的 SFT 和 SSAT 从 M1 到 M4 下降，而正常体重女性则保持稳定。对于所有 BMI 类别，SFT 和 SSAT 在产后增加。肥胖和超重女性的 DSAT 明显下降，正常体重女性的 DSAT 明显增加。肥胖女性在 M1 时的 D/S 较高，在 M2 时下降，产后保持不变。超重女性的 D/S 在 M2 时增加，然后在 M3 时下降。正常体重女性在 M2-M4 期间增加 D/S。
结果表明，在不同 BMI 类别中，腹部皮下脂肪的 SSAT 和 DSAT 分布和动员存在差异。了解怀孕期间脂肪的动员方式可能对于理解肥胖相关并发症至关重要。
