Steinbach J H, Merlie J, Heinemann S, Bloch R
Proc Natl Acad Sci U S A. 1979 Jul;76(7):3547-51. doi: 10.1073/pnas.76.7.3547.
We have examined the rate of degradation of the total acetylcholine receptor content of diaphragm muscles of young rats and have found that even in muscles from 1-day-old rats some receptors are metabolically more stable than adult extrajunctional receptors. Further experiments have shown that acetylcholine receptors at junctional regions from young rats are degraded slowly, whereas those in extrajunctional regions are degraded rapidly. The results demonstrate that junctional acetylcholine receptors in rat diaphragm are degraded at a slow rate characteristic of adult junctional receptors at all ages after birth.
我们检测了幼鼠膈肌中总乙酰胆碱受体含量的降解速率，发现即使是1日龄大鼠的肌肉中，一些受体在代谢上也比成年肌外受体更稳定。进一步的实验表明，幼鼠神经肌肉接头区域的乙酰胆碱受体降解缓慢，而肌外区域的受体降解迅速。结果表明，大鼠膈肌中的接头乙酰胆碱受体在出生后的所有年龄段均以成年接头受体特有的缓慢速率降解。
