Sawazaki Sho, Oshima Takashi, Sakamaki Kentaro, Aoyama Toru, Sato Tsutomu, Shiozawa Manabu, Yoshikawa Takaki, Rino Yasushi, Imada Toshio, Masuda Munetaka
Department of Surgery, Yokohama City University, Yokohama, Japan.
Department of Surgery, Yokohama City University, Yokohama, Japan
In Vivo. 2017 Nov-Dec;31(6):1065-1071. doi: 10.21873/invivo.11171.
Overall survival remains unsatisfactory in stage II/III gastric cancer, even after curative resection and adjuvant chemotherapy. Tensin 4 (TNS4), a cell adhesion factor, is associated with cancer-cell motility and migration.
We examined the clinical significance of TNS4 gene expression in 134 patients with stage II/III gastric cancer who underwent adjuvant chemotherapy with S-1. TNS4 gene expression in surgical specimens was measured by quantitative reverse-transcription polymerase chain reaction (RT-PCR).
TNS4 gene expression levels were significantly higher in cancer tissue than in adjacent normal mucosa. High TNS4 gene expression was associated with significantly poorer 5-year overall survival than was low expression. On multivariate analysis, TNS4 gene expression was an independent prognostic factor.
Overexpression of the TNS4 gene is a useful independent predictor of outcomes in patients with stage II/III gastric cancer who undergo surgery and receive adjuvant chemotherapy with S-1.
即使在进行根治性切除和辅助化疗后,II/III期胃癌患者的总生存期仍不尽人意。张力蛋白4(TNS4)是一种细胞粘附因子,与癌细胞的运动性和迁移有关。
我们检测了134例接受S-1辅助化疗的II/III期胃癌患者中TNS4基因表达的临床意义。通过定量逆转录聚合酶链反应(RT-PCR)测定手术标本中的TNS4基因表达。
癌组织中TNS4基因表达水平显著高于相邻正常黏膜。与低表达相比,高TNS4基因表达与5年总生存期显著较差相关。多因素分析显示,TNS4基因表达是一个独立的预后因素。
TNS4基因的过表达是接受手术并接受S-1辅助化疗的II/III期胃癌患者预后的一个有用的独立预测指标。