Kwak Heewon A, Hart John
Department of Pathology, University of Chicago, 5841 South Maryland Avenue, Chicago, IL, USA.
Department of Pathology, University of Chicago, 5841 South Maryland Avenue, MC 6101, Chicago, IL, USA.
Surg Pathol Clin. 2017 Dec;10(4):887-908. doi: 10.1016/j.path.2017.07.007.
Every year many new medications are approved for clinical use, several of which can cause clinically significant gastrointestinal tract toxicity. This article emphasizes the histologic features and differential diagnosis of drug-induced injury to the gastrointestinal mucosa. Ultimately, clinical correlation and cessation of a drug with resolution of symptoms are needed to definitively confirm a drug as a causative factor in mucosal injury. Recognizing histologic features in gastrointestinal biopsies, however, can allow surgical pathologists to play a key role in establishing a diagnosis of drug-induced gastrointestinal toxicity.
每年都有许多新药物被批准用于临床，其中几种可导致具有临床意义的胃肠道毒性。本文着重介绍药物性胃肠黏膜损伤的组织学特征和鉴别诊断。最终，需要临床关联以及停用药物后症状缓解才能明确证实某药物是黏膜损伤的致病因素。然而，识别胃肠道活检中的组织学特征可使外科病理学家在确立药物性胃肠道毒性的诊断中发挥关键作用。
