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基因检测作为一种识别患有眼部疾病或有眼部疾病风险马匹的工具。

Genetic Testing as a Tool to Identify Horses with or at Risk for Ocular Disorders.

作者信息

Bellone Rebecca R

机构信息

Department of Population Health and Reproduction, Veterinary Genetics Laboratory, UC Davis School of Veterinary Medicine, One Shields Avenue, Davis, CA 95616, USA.

出版信息

Vet Clin North Am Equine Pract. 2017 Dec;33(3):627-645. doi: 10.1016/j.cveq.2017.08.005.

Abstract

Advances in equine genetics and genomics resources have enabled the understanding of some inherited ocular disorders and ocular manifestations. These ocular disorders include congenital stationary night blindness, equine recurrent uveitis, multiple congenital ocular anomalies, and squamous cell carcinoma. Genetic testing can identify horses with or at risk for disease and thus can assist in clinical management. In addition, genetic testing can identify horses that are carriers and thus can inform breeding decisions. Use of genetic tests in management and breeding decisions should aid in reducing the incidence of these disorders and improving the outcomes for horses at highest risk.

摘要

马遗传学和基因组学资源的进展使得人们能够了解一些遗传性眼部疾病和眼部表现。这些眼部疾病包括先天性静止性夜盲、马复发性葡萄膜炎、多发性先天性眼部异常和鳞状细胞癌。基因检测可以识别患有疾病或有患病风险的马匹,从而有助于临床管理。此外,基因检测可以识别携带疾病基因的马匹,从而为繁殖决策提供信息。在管理和繁殖决策中使用基因检测应有助于降低这些疾病的发病率,并改善高危马匹的预后。

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