核酸适体在神经退行性疾病中的应用。

Nucleic acid aptamers for neurodegenerative diseases.

机构信息

CEA, Fundamental Research Division (DRF), Institute of Biology François Jacob (Jacob), Molecular Imaging Research Center, 18 Route du Panorama, 92265 Fontenay-aux-Roses, France; Neurodegenerative Diseases Laboratory, CNRS CEA UMR 9199, Fontenay-aux-Roses, France; Paris-Saclay University, Paris-Sud University, Fontenay-aux-Roses, France.

出版信息

Biochimie. 2018 Feb;145:73-83. doi: 10.1016/j.biochi.2017.10.026. Epub 2017 Nov 20.

DOI:10.1016/j.biochi.2017.10.026

PMID:29104136

Abstract

The increased incidence of neurodegenerative diseases represents a huge challenge for societies. These diseases are characterized by neuronal death and include several different pathologies, such as Alzheimer's disease, Parkinson's disease, multiple sclerosis, Huntington's disease and transmissible spongiform encephalopathies. Most of these pathologies are often associated with the aggregation of misfolded proteins, such as amyloid-ß, tau, α-synuclein, huntingtin and prion proteins. However, the precise mechanisms that lead to neuronal dysfunction and death in these diseases remain poorly understood. Nucleic acid aptamers represent a new class of ligands that could be useful to better understand these diseases and develop better diagnosis and therapy. In this review, several of these aptamers are presented as well as their applications for neurodegenerative diseases.

摘要

神经退行性疾病发病率的增加对社会构成了巨大挑战。这些疾病的特征是神经元死亡，包括几种不同的病理学，如阿尔茨海默病、帕金森病、多发性硬化症、亨廷顿病和传染性海绵状脑病。这些病理学中的大多数通常与错误折叠蛋白的聚集有关，如淀粉样蛋白-β、tau、α-突触核蛋白、亨廷顿蛋白和朊病毒蛋白。然而，导致这些疾病中神经元功能障碍和死亡的确切机制仍知之甚少。核酸适体代表了一类新的配体，它们可能有助于更好地理解这些疾病，并开发更好的诊断和治疗方法。在这篇综述中，介绍了其中的几种适体及其在神经退行性疾病中的应用。