Laboratory of Practical Pharmacy and Pharmaceutical Care, Faculty of Pharmacy, Osaka Ohtani University.
Laboratory of Environmental Science and Microbiology, Faculty of Pharmacy, Osaka Ohtani University.
Int J Med Sci. 2017 Sep 19;14(12):1213-1219. doi: 10.7150/ijms.21424. eCollection 2017.
Peripheral parenteral nutrition (PPN) solutions contain amino acids, glucose, and electrolytes, with or without some water soluble vitamins. Peripheral venous catheters are one of the causes of catheter related blood stream infection (CRBSI), which requires infection control. In Japan, PPN solutions have rarely been prepared under aseptic conditions. However, in recent years, the necessity of adding vitamins to infusions has been reported. Therefore, we investigated the effects of water soluble vitamins on growth of microorganisms in PPN solutions. AMINOFLUID (AF), BFLUID (BF), PARESAFE (PS) and PAREPLUS (PP) PPN solutions were used. Water soluble vitamins contained in PP were also used. Causative microorganisms of CRBSI were used. decreased after 24 hours or 48 hours in all solutions. On the other hand, , , and increased, especially in PP. When each water soluble vitamin was added to BF and PS, growth of was greater in solutions that contained nicotinamide than in solutions that contained other vitamins. As for , they grew in all test solutions. grew especially well in solutions that contained biotin. When commercial amino acids and glucose solutions with electrolytes are administered, in particular those containing multivitamins or water soluble vitamins, efforts to control infection must be taken to prevent proliferation of microorganisms.
外周肠外营养（PPN）溶液含有氨基酸、葡萄糖和电解质，可添加或不添加一些水溶性维生素。外周静脉导管是导管相关血流感染（CRBSI）的原因之一，需要进行感染控制。在日本，PPN 溶液很少在无菌条件下配制。然而，近年来，据报道在输液中添加维生素是必要的。因此，我们研究了水溶性维生素对 PPN 溶液中微生物生长的影响。使用了 AMINOFLUID（AF）、BFLUID（BF）、PARESAFE（PS）和 PAREPLUS（PP）PPN 溶液。还使用了 PP 中含有的水溶性维生素。使用了 CRBSI 的病原体微生物。所有溶液中 24 小时或 48 小时后 减少。另一方面， 、 、 和 增加，特别是在 PP 中。当将每种水溶性维生素添加到 BF 和 PS 中时，含有烟酰胺的溶液中 的生长大于含有其他维生素的溶液。对于 ，它们在所有测试溶液中生长。含有生物素的溶液中 生长良好。当给予含有电解质的商业氨基酸和葡萄糖溶液时，特别是那些含有多种维生素或水溶性维生素的溶液时，必须采取感染控制措施以防止微生物增殖。
