转化生长因子α TaqI 多态性与伊朗人群唇裂和/或腭裂风险的关联研究。
Association Study of Transforming Growth Factor Alpha TaqI Polymorphism and the Risk of Cleft Lip and/or Palate in an Iranian Population.
机构信息
Orthodontist private practice, Tehran, Iran.
Dentofacial Deformities Research Center, Research Institute of Dental Sciences, Department of Orthodontics, Faculty of Dentistry, Shahid Behehsti University of Medical Sciences, Tehran, Iran.
出版信息
Birth Defects Res. 2017 Oct 16;109(17):1386-1389. doi: 10.1002/bdr2.1125.
BACKGROUND
The aim of this study is to evaluate the association of TGFA TaqI polymorphism with nonsyndromic cleft lip and/or palate (NSCLP) in an Iranian population.
METHODS
In this case-control study, 113 children with NSCLP and 209 controls were included. Genotyping of the TaqI polymorphism was performed by polymerase chain reaction and restriction fragment length polymorphism methods. A p-value of <0.05 was considered statistically significant.
RESULTS
For the TGFA TaqI polymorphism, the distributions of genotypes in the NSCLP (p = 0.810) and control group (p = 0.422) were in Hardy-Weinberg equilibrium. There was no statistically significant difference in the genotype distribution (p = 0.059) and allele frequency (p = 0.065) of the TGFA TaqI polymorphism in the NSCLP and control groups.
CONCLUSION
TGFA TaqI polymorphism was not associated with the risk of NSCLP in Iranian children. Birth Defects Research 109:1386-1389, 2017.© 2017 Wiley Periodicals, Inc.
背景
本研究旨在评估 TGFA TaqI 多态性与伊朗人群中非综合征性唇腭裂（NSCLP）的关联。
方法
在这项病例对照研究中，纳入了 113 名 NSCLP 患儿和 209 名对照。通过聚合酶链反应和限制性片段长度多态性方法对 TaqI 多态性进行基因分型。p 值<0.05 被认为具有统计学意义。
结果
对于 TGFA TaqI 多态性，NSCLP 组（p=0.810）和对照组（p=0.422）的基因型分布均处于哈迪-温伯格平衡状态。NSCLP 组和对照组的 TGFA TaqI 多态性基因型分布（p=0.059）和等位基因频率（p=0.065）无统计学差异。
结论
在伊朗儿童中，TGFA TaqI 多态性与 NSCLP 的风险无关。出生缺陷研究 109:1386-1389, 2017.© 2017 Wiley Periodicals, Inc.
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