评估一种用于预测核苷抗白血病活性的共同受体-补体概念。
Evaluation of a common receptor-complement concept for predicting the antileukemic activity of nucleosides.
作者信息
Townsend L B, Schram K H, Beránek J
出版信息
Proc Natl Acad Sci U S A. 1979 Aug;76(8):4075-8. doi: 10.1073/pnas.76.8.4075.
Abstract
The triangulation arrangement of one nitrogen and two oxygen atoms proposed as a requirement for antileukemic activity involving a "common receptor-complement feature" has been reevaluated specifically as it applies to nucleosides. This re-evaluation has resulted in a rejection of the "receptor-complement feature" as a working model for the a priori design of nucleosides as compounds active against leukemia L-1210.
摘要
作为具有“共同受体-互补特征”的抗白血病活性要求而提出的一个氮原子和两个氧原子的三角排列，已特别针对核苷进行了重新评估。这种重新评估导致否定了“受体-互补特征”作为核苷作为抗白血病L-1210活性化合物的先验设计的工作模型。
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Evaluation of a common receptor-complement concept for predicting the antileukemic activity of nucleosides.评估一种用于预测核苷抗白血病活性的共同受体-补体概念。
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本文引用的文献
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Common receptor-complement feature among some antileukemic compounds.
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Incorporation of analog purine nucleosides into the formed elements of human blood: erythrocytes, platelets, and lymphocytes.将类似嘌呤核苷掺入人血的有形成分：红细胞、血小板和淋巴细胞。
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Synthesis of 2-amino-5-cyano-7-(beta-D-ribofuranosyl)-pyrrolo[2,3-d]pyrimidin-4-one. An important precursor for the synthesis of nucleoside Q and Q.2-氨基-5-氰基-7-（β-D-呋喃核糖基）-吡咯并[2,3-d]嘧啶-4-酮的合成。核苷Q和Q合成的重要前体。
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