评估一种用于预测核苷抗白血病活性的共同受体-补体概念。
Evaluation of a common receptor-complement concept for predicting the antileukemic activity of nucleosides.
作者信息
Townsend L B, Schram K H, Beránek J
出版信息
Proc Natl Acad Sci U S A. 1979 Aug;76(8):4075-8. doi: 10.1073/pnas.76.8.4075.
Abstract
The triangulation arrangement of one nitrogen and two oxygen atoms proposed as a requirement for antileukemic activity involving a "common receptor-complement feature" has been reevaluated specifically as it applies to nucleosides. This re-evaluation has resulted in a rejection of the "receptor-complement feature" as a working model for the a priori design of nucleosides as compounds active against leukemia L-1210.
摘要
作为具有“共同受体-互补特征”的抗白血病活性要求而提出的一个氮原子和两个氧原子的三角排列，已特别针对核苷进行了重新评估。这种重新评估导致否定了“受体-互补特征”作为核苷作为抗白血病L-1210活性化合物的先验设计的工作模型。
相似文献
1
Evaluation of a common receptor-complement concept for predicting the antileukemic activity of nucleosides.评估一种用于预测核苷抗白血病活性的共同受体-补体概念。
Proc Natl Acad Sci U S A. 1979 Aug;76(8):4075-8. doi: 10.1073/pnas.76.8.4075.
2
Preparation and antileukemic screening of some new 6'-deoxyhexopyranosyladenine nucleosides.
J Med Chem. 1987 Aug;30(8):1521-5. doi: 10.1021/jm00391a044.
3
[Antitumor effects of keto-nucleosides. Study of the antitumor activity of y(3'-O-acetyl-4', 6'-dideoxy-beta-L-glycero-hex-3'-eno-pyranosyl) theophylline and 1(4'-keto-2'-3'-O-isopropylidene-alpha-L-''rhamnosyl''O thymine against L 1210 leukemia in mice].[酮核苷的抗肿瘤作用。γ（3'-O-乙酰基-4'，6'-二脱氧-β-L-甘油-己-3'-烯吡喃糖基）茶碱和1（4'-酮-2'-3'-O-异亚丙基-α-L-“鼠李糖基”O胸腺嘧啶对小鼠L 1210白血病的抗肿瘤活性研究]
C R Acad Hebd Seances Acad Sci D. 1977 Oct 17;285(9):1021-4.
4
The in vivo activity of combinations of 5-azacytidine and cytidine on leukemia L-1210.5-氮杂胞苷与胞苷联合用药对白血病L-1210的体内活性
Experientia. 1968 Sep 15;24(9):922-3. doi: 10.1007/BF02138656.
5
Synthesis and antileukemic activity of certain D-fucopyranosyl nucleosides.某些D-吡喃岩藻糖基核苷的合成及其抗白血病活性
Carbohydr Res. 1993 Jun 21;244(2):285-94. doi: 10.1016/0008-6215(83)85008-3.
6
[Synergistic effect of nucleoside and cyclophosphamide combination in murine L 1210 leukemia].[核苷与环磷酰胺联合应用对小鼠L1210白血病的协同作用]
Verh Dtsch Ges Inn Med. 1975;81:1109-11.
7
6,6'-Dithiobispurinyl nucleosides.6,6'-二硫代双嘌呤核苷
J Med Chem. 1969 Nov;12(6):1117-8. doi: 10.1021/jm00306a043.
8
Methanesulfonates: the relationship of structure to antitumor activity.
Cancer Chemother Rep 2. 1972 Nov;3(1):137-229.
9
Analysis of the in vitro antitumor activity of novel purine-6-sulfenamide, -sulfinamide, and -sulfonamide nucleosides and certain related compounds using a computer-aided receptor modeling procedure.
J Med Chem. 1991 Feb;34(2):526-32. doi: 10.1021/jm00106a007.
10
Deamination of arabinosyladenine by adenosine deaminase and inhibition by arabinosyl-6-mercaptopurine.腺苷脱氨酶对阿糖腺苷的脱氨作用及阿糖基-6-巯基嘌呤的抑制作用。
Cancer Res. 1972 Aug;32(8):1721-4.
本文引用的文献
1
Common receptor-complement feature among some antileukemic compounds.某些抗白血病化合物之间常见的受体-补体特征。
J Pharm Sci. 1970 Nov;59(11):1630-4. doi: 10.1002/jps.2600591118.
2
Incorporation of analog purine nucleosides into the formed elements of human blood: erythrocytes, platelets, and lymphocytes.将类似嘌呤核苷掺入人血的有形成分：红细胞、血小板和淋巴细胞。
Ann N Y Acad Sci. 1975 Aug 8;255:412-34. doi: 10.1111/j.1749-6632.1975.tb29249.x.
3
Comparative study by circular dichroism of the conformation of deazapurine nucleosides and that of common purine nucleosides.通过圆二色性对脱氮嘌呤核苷与常见嘌呤核苷构象的比较研究。
Proc Natl Acad Sci U S A. 1976 Jul;73(7):2384-7. doi: 10.1073/pnas.73.7.2384.
4
Synthesis, chemical reactivity, and chemotherapeutic activity of certain selenonucleosides and nucleosides related to the pyrrolo(2,3-d)pyrimidine nucleoside antibiotics.某些与吡咯并(2,3 - d)嘧啶核苷抗生素相关的硒代核苷和核苷的合成、化学反应性及化疗活性
Ann N Y Acad Sci. 1975 Aug 8;255:91-103. doi: 10.1111/j.1749-6632.1975.tb29216.x.
5
Synthesis of 2-amino-5-cyano-7-(beta-D-ribofuranosyl)-pyrrolo[2,3-d]pyrimidin-4-one. An important precursor for the synthesis of nucleoside Q and Q.2-氨基-5-氰基-7-（β-D-呋喃核糖基）-吡咯并[2,3-d]嘧啶-4-酮的合成。核苷Q和Q合成的重要前体。
J Am Chem Soc. 1976 Nov 24;98(24):7870-2. doi: 10.1021/ja00440a094.
6
Biochemical properties of the nucleoside of 3-amino-1,5-dihydro-5-methyl-1,4,5,6,8-pentaazaacenaphthylene (NSC-154020).3-氨基-1,5-二氢-5-甲基-1,4,5,6,8-五氮杂苊烯（NSC-154020）核苷的生化特性
Biochem Pharmacol. 1978 Jan 15;27(2):233-41. doi: 10.1016/0006-2952(78)90306-4.
7
Specificity of adenosine deaminase inhibitors.
Biochem Pharmacol. 1977 Nov 1;26(21):1967-72. doi: 10.1016/0006-2952(77)90003-x.
8
N-Methylformycins. Reactivity with adenosine deaminase, incorporation into intracellular nucleotides of human erythrocytes and L 1210 cells and cytotoxicity to L 1210 cells.N-甲基间型霉素。与腺苷脱氨酶的反应性、掺入人红细胞和L 1210细胞的细胞内核苷酸以及对L 1210细胞的细胞毒性。
Biochem Pharmacol. 1979 May 1;28(9):1491-500. doi: 10.1016/0006-2952(79)90463-5.
9
Adenosine analogs and human platelets--II. Inhibition of ADP-induced aggregation by carbocyclic adenosine and imidazole-ring modified analogs. Significance of alterations in the nucleotide pools.腺苷类似物与人类血小板——II. 碳环腺苷和咪唑环修饰类似物对二磷酸腺苷诱导的聚集的抑制作用。核苷酸池改变的意义。
Biochem Pharmacol. 1979;28(4):501-10. doi: 10.1016/0006-2952(79)90243-0.
10
Transport, phosphorylation, and toxicity of a tricyclic nucleoside in cultured Novikoff rat hepatoma cells and other cell lines and relase of its monophosphate by the cells.三环核苷在培养的诺维科夫大鼠肝癌细胞及其他细胞系中的转运、磷酸化和毒性以及细胞对其一磷酸酯的释放
J Natl Cancer Inst. 1976 Dec;57(6):1283-95. doi: 10.1093/jnci/57.6.1283.
Zotero 插件