Department of Oncology and Metabolism, University of Sheffield, Sheffield, UK.
Department of Automatic Control and Systems Engineering, University of Sheffield, Sheffield, UK.
Clin Endocrinol (Oxf). 2018 Jun;88(6):772-778. doi: 10.1111/cen.13509. Epub 2017 Nov 29.
Salivary cortisone reflects serum cortisol levels, is more sensitive than salivary cortisol at lower values of serum cortisol and is noninvasive.
To investigate the relationship between serum cortisol and salivary cortisol and cortisone following low- and high-dose synacthen.
Prospective pharmacodynamic studies in clinical research facilities.
Thirty-five dexamethasone-suppressed, healthy adult males underwent an intravenous synacthen test: N = 23 low-dose (1 mcg), N = 12 high-dose (250 mcg). Paired serum and salivary samples were taken at 15 sampling points over 120 minutes.
Serum cortisol and salivary cortisol and cortisone were analysed for correlations and by a mixed-effects model.
At baseline, the correlation between serum cortisol and salivary cortisol was weak with many samples undetectable (r = .45, NS), but there was a strong correlation with salivary cortisone (r = .94, P < .001). Up to 50 minutes following synacthen, the correlation coefficient between serum cortisol and salivary cortisol and cortisone was <0.8, but both had a stronger correlation at 60 minutes (salivary cortisol r = .89, P < .001, salivary cortisone r = .85, P < .001). The relationship was examined excluding samples in the dynamic phase (baseline to 60 minutes). Salivary cortisol and cortisone showed a close relationship to serum cortisol. Salivary cortisone showed the stronger correlation: salivary cortisol r = .82, P < .001, salivary cortisone r = .96, P < .001.
Following synacthen, both salivary cortisol and cortisone reflect serum cortisol levels, but there is a lag in their rise up to 60 minutes. The results support further research for possible future use of a 60-minute salivary cortisone measurement during the synacthen test.
唾液皮质醇反映了血清皮质醇水平，在较低的血清皮质醇水平下，其灵敏度高于唾液皮质醇，并且是非侵入性的。
研究低剂量和高剂量促肾上腺皮质激素（synacthen）后血清皮质醇与唾液皮质醇和皮质酮之间的关系。
临床研究设施中的前瞻性药效动力学研究。
35 名接受地塞米松抑制的健康成年男性接受了静脉注射 synacthen 试验：N = 23 名低剂量（1 mcg），N = 12 名高剂量（250 mcg）。在 120 分钟的 15 个采样点采集配对的血清和唾液样本。
分析血清皮质醇和唾液皮质醇及皮质酮的相关性，并采用混合效应模型进行分析。
在基线时，血清皮质醇与唾液皮质醇之间的相关性较弱，许多样本无法检测到（r =.45，NS），但与唾液皮质酮之间的相关性很强（r =.94，P <.001）。在 synacthen 后长达 50 分钟时，血清皮质醇与唾液皮质醇和皮质酮之间的相关系数<0.8，但在 60 分钟时相关性更强（唾液皮质醇 r =.89，P <.001，唾液皮质酮 r =.85，P <.001）。检查了排除动态相（基线至 60 分钟）内样本的关系。唾液皮质醇和皮质酮与血清皮质醇密切相关。唾液皮质酮显示出更强的相关性：唾液皮质醇 r =.82，P <.001，唾液皮质酮 r =.96，P <.001。
在 synacthen 后，唾液皮质醇和皮质酮均反映了血清皮质醇水平，但在 60 分钟内其上升存在滞后。这些结果支持进一步研究，以可能在 synacthen 试验中使用 60 分钟唾液皮质酮测量值。
