Yoder Nicole, Marks Asher, Hui Pei, Litkouhi Babak, Cron Julia
Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University, School of Medicine, New Haven, Connecticut.
Department of Pediatric Hematology/Oncology, Yale University, School of Medicine, New Haven, Connecticut.
J Pediatr Adolesc Gynecol. 2018 Jun;31(3):325-327. doi: 10.1016/j.jpag.2017.10.005. Epub 2017 Oct 26.
Mature cystic teratomas are the most common ovarian neoplasm in adolescents. They are typically benign, however, malignant transformation rarely occurs. We report a low-grade astrocytoma arising from a mature cystic teratoma in an adolescent patient.
The patient was a 12-year-old girl with an asymptomatic ovarian cyst and subsequent cystectomy. Final pathology identified a solid tumor with glial tissue within the cyst, reported as low-grade astrocytoma arising in a mature cystic teratoma.
There are few data on astrocytomas in the gynecologic tract. Risk factors for malignant transformation in a mature cystic teratoma include increased age, postmenopausal status, elevated carcinoma antigen 125, and large tumor size. Interestingly, this patient had a history of partial trisomy 20, which has been associated with teratoma formation in a mouse model.
成熟囊性畸胎瘤是青少年中最常见的卵巢肿瘤。它们通常是良性的，然而，恶变很少发生。我们报告一例青少年患者，其成熟囊性畸胎瘤发生了低级别星形细胞瘤。
该患者为一名12岁女孩，有一个无症状的卵巢囊肿，随后接受了囊肿切除术。最终病理检查发现囊肿内有一个伴有神经胶质组织的实性肿瘤，报告为成熟囊性畸胎瘤内发生的低级别星形细胞瘤。
关于生殖道星形细胞瘤的数据很少。成熟囊性畸胎瘤恶变的危险因素包括年龄增加、绝经后状态、癌抗原125升高和肿瘤体积大。有趣的是，该患者有20号染色体部分三体的病史，这在小鼠模型中与畸胎瘤形成有关。
